Die GABA A-rezeptor-familie. Möglichkeiten für die entwicklung besserer anästhetika

Translated title of the contribution: The GABA A receptor family. Possibilities for the development of better anesthetics

B. Drexler, C. Grasshoff, U. Rudolph, K. Unertl, B. Antkowiak

Research output: Contribution to journalArticlepeer-review

Abstract

Clinically used anesthetics show amnestic, sedative, hypnotic and immobilizing properties. On a molecular level these drugs affect several receptors in the cell membrane of neurons. By using genetically engineered mice a linkage can now be made between actions on certain receptors and clinically desired and undesired effects. Experiments show that a certain GABA A receptor subtype mediates hypnosis and immobility, whereas another subtype is involved in side-effects like sedation and hypothermia. These findings form the basis for the development of new drugs, acting highly specific and with fewer side-effects.

Translated title of the contributionThe GABA A receptor family. Possibilities for the development of better anesthetics
Original languageGerman
Pages (from-to)287-295
Number of pages9
JournalAnaesthesist
Volume55
Issue number3
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

Keywords

  • Benzodiazepines
  • GABA receptor subtypes
  • Intravenous anesthetics
  • Knock-in-mice
  • Side-effects

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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