The functional make up of proteomes is remarkably conserved

A. Nasir, A. Naeem, M. J. Khan, H. D. Lopez-Nicora, Gustavo Caetano-Anolles

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here we analyze the functional annotation of protein domains in almost a thousand sequenced genomes. Our results yield fundamental insights into the structural and functional diversity of proteomes. We find that the functional makeup of proteomes is remarkably conserved across cellular superkingdoms. In general, most of the proteome repertoire is spent for functions related to metabolic processes but there are significant differences in the usage of protein domains both between and within superkingdoms. Our results provide support to the hypotheses that the proteomes of the eukaryal superkingdom evolved via genome expansion mechanisms while those of microbial superkingdoms evolved by reductive evolutionary processes. We also identify few genomic outlier groups in each superkingdom that deviate significantly from the conserved functional design. These genomes are reduced and belong to parasitic organisms.

Original languageEnglish (US)
Title of host publication2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
Pages1023-1025
Number of pages3
DOIs
StatePublished - 2011
Event2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011 - Atlanta, GA, United States
Duration: Nov 12 2011Nov 15 2011

Other

Other2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
CountryUnited States
CityAtlanta, GA
Period11/12/1111/15/11

Fingerprint

Proteome
Proteins
Genome
Genes
Protein Domains

Keywords

  • fold superfamily
  • functional annotation
  • molecular function
  • protein domain
  • SCOP
  • structure
  • superkingdom

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

Cite this

Nasir, A., Naeem, A., Khan, M. J., Lopez-Nicora, H. D., & Caetano-Anolles, G. (2011). The functional make up of proteomes is remarkably conserved. In 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011 (pp. 1023-1025). [6112546] https://doi.org/10.1109/BIBMW.2011.6112546

The functional make up of proteomes is remarkably conserved. / Nasir, A.; Naeem, A.; Khan, M. J.; Lopez-Nicora, H. D.; Caetano-Anolles, Gustavo.

2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011. 2011. p. 1023-1025 6112546.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nasir, A, Naeem, A, Khan, MJ, Lopez-Nicora, HD & Caetano-Anolles, G 2011, The functional make up of proteomes is remarkably conserved. in 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011., 6112546, pp. 1023-1025, 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011, Atlanta, GA, United States, 11/12/11. https://doi.org/10.1109/BIBMW.2011.6112546
Nasir A, Naeem A, Khan MJ, Lopez-Nicora HD, Caetano-Anolles G. The functional make up of proteomes is remarkably conserved. In 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011. 2011. p. 1023-1025. 6112546 https://doi.org/10.1109/BIBMW.2011.6112546
Nasir, A. ; Naeem, A. ; Khan, M. J. ; Lopez-Nicora, H. D. ; Caetano-Anolles, Gustavo. / The functional make up of proteomes is remarkably conserved. 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011. 2011. pp. 1023-1025
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