The FMR1 premutation phenotype and mother-youth synchrony in fragile X syndrome

Carly Moser, Laura Mattie, Leonard Abbeduto, Jessica Klusek

Research output: Contribution to journalArticlepeer-review


A subset of mothers who carry the FMR1 premutation may express a unique phenotype. The relationship between the FMR1 phenotype and mother-child interaction in families with fragile X-associated disorders has not been well characterized, despite the importance of high-quality mother-child interaction for child development. This study examined the association between the FMR1 phenotype and the quality of interactions between mothers and their adolescent/young adult sons with fragile X syndrome. Mother-youth synchrony was coded from a dyadic interaction. Maternal anxiety and depression symptoms, executive function deficits, and pragmatic language difficulties were evaluated. Results indicated that pragmatic language was associated with mother-youth synchrony. These findings highlight the importance of family-centered intervention practices for families with fragile X-associated disorders.

Original languageEnglish (US)
Pages (from-to)443-459
Number of pages17
JournalAmerican journal on intellectual and developmental disabilities
Issue number6
StatePublished - Nov 1 2021


  • FXS
  • Fragile X carrier
  • Mother-child interaction
  • Pragmatic language

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Psychiatry and Mental health


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