The Fe(PDP)-catalyzed aliphatic C-H oxidation: a slow addition protocol

Nicolaas A. Vermeulen, Mark S. Chen, M. Christina White

Research output: Contribution to journalArticlepeer-review

Abstract

This report describes a slow addition protocol for the Fe(PDP)-catalyzed aliphatic C-H oxidation reaction. Under this protocol, the reaction can be productively driven to higher conversions without decreasing site-selectivity or chemoselectivity. The operational advantages of this procedure are highlighted in the oxidation of two complex natural product derivatives. Hydroxylated products can be obtained in high isolated yields without the need for recycling recovered starting materials.

Original languageEnglish (US)
Pages (from-to)3078-3084
Number of pages7
JournalTetrahedron
Volume65
Issue number16
DOIs
StatePublished - Apr 18 2009

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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