@article{6f94418c551e490e94c26fae669b259b,
title = "The Fe(PDP)-catalyzed aliphatic C-H oxidation: a slow addition protocol",
abstract = "This report describes a slow addition protocol for the Fe(PDP)-catalyzed aliphatic C-H oxidation reaction. Under this protocol, the reaction can be productively driven to higher conversions without decreasing site-selectivity or chemoselectivity. The operational advantages of this procedure are highlighted in the oxidation of two complex natural product derivatives. Hydroxylated products can be obtained in high isolated yields without the need for recycling recovered starting materials.",
author = "Vermeulen, {Nicolaas A.} and Chen, {Mark S.} and {Christina White}, M.",
note = "Funding Information: We are grateful to the A.P Sloan Foundation, the Camille and Henry Dreyfus Foundation, Bristol-Myers Squibb, Pfizer, Amgen, Eli Lilly, Merck Research Laboratories, Abbott Laboratories, AstraZeneca, and the University of Illinois for financial support and generous gifts. N.A.V. gratefully acknowledges Pfizer for a graduate fellowship. M.S.C. is a Harvard University graduate student completing doctoral work with M.C.W. at the University of Illinois at Urbana-Champaign. M.S.C. gratefully acknowledges Bristol-Myers Squibb for a graduate fellowship. We thank M.A. Bigi for performing the oxidative lactonization of 4-methylvaleric acid, and E.M. Stang for verifying the hydroxylation results of artemisinin. Both M.A.B. and E.M.S. are thanked for helpful discussions in the writing of this manuscript. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",
year = "2009",
month = apr,
day = "18",
doi = "10.1016/j.tet.2008.11.082",
language = "English (US)",
volume = "65",
pages = "3078--3084",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "16",
}