The Fe(PDP)-catalyzed aliphatic C-H oxidation: a slow addition protocol

Nicolaas A. Vermeulen; Mark S. Chen; M. Christina White

doi:10.1016/j.tet.2008.11.082

The Fe(PDP)-catalyzed aliphatic C-H oxidation: a slow addition protocol

Nicolaas A. Vermeulen, Mark S. Chen, M. Christina White

Research output: Contribution to journal › Article › peer-review

Abstract

This report describes a slow addition protocol for the Fe(PDP)-catalyzed aliphatic C-H oxidation reaction. Under this protocol, the reaction can be productively driven to higher conversions without decreasing site-selectivity or chemoselectivity. The operational advantages of this procedure are highlighted in the oxidation of two complex natural product derivatives. Hydroxylated products can be obtained in high isolated yields without the need for recycling recovered starting materials.

Original language	English (US)
Pages (from-to)	3078-3084
Number of pages	7
Journal	Tetrahedron
Volume	65
Issue number	16
DOIs	https://doi.org/10.1016/j.tet.2008.11.082
State	Published - Apr 18 2009

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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abstract = "This report describes a slow addition protocol for the Fe(PDP)-catalyzed aliphatic C-H oxidation reaction. Under this protocol, the reaction can be productively driven to higher conversions without decreasing site-selectivity or chemoselectivity. The operational advantages of this procedure are highlighted in the oxidation of two complex natural product derivatives. Hydroxylated products can be obtained in high isolated yields without the need for recycling recovered starting materials.",

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