The fast protein folding problem

Research output: Contribution to journalArticlepeer-review


During protein folding, many of the events leading to secondary and tertiary structure occur in milliseconds or faster. Modern nuclear magnetic resonance and laser detection techniques, coupled with fast initiation of the folding reaction, are probing these events in great detail. Theory, ranging from analytical models to molecular dynamics calculations, is beginning to match up with experiment. As a result, timescales, from such elementary steps as the addition of a residue to a helix to strange kinetics of collapsing protein backbones, can now be measured and interpreted.

Original languageEnglish (US)
Pages (from-to)485-516
Number of pages32
JournalAnnual Review of Physical Chemistry
StatePublished - 1999


  • Cold denaturation
  • Energy landscape
  • Hydrophobic collapse
  • Protein engineering
  • Secondary structure
  • Strange kinetics
  • Temperature jump

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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