The Exposome in Toxicologic Pathology

Brad Bolon, Wanda M. Haschek

Research output: Contribution to journalReview article

Abstract

The “exposome” is an individual’s lifetime spectrum of chemical exposures beginning at conception. An exposome includes general external influences such as pollution and weather; external individual-specific factors (diet, infections, self-selected chemical intake); and internal individual-specific constituents (metabolic byproducts, microbiome derivatives, inflammatory mediators, stress hormones, etc). The exposome paradigm is inherent in animal toxicity testing because laboratory studies are designed so that subjects share a common exposure history encompassing not only exposure(s)/treatment(s) but also other chemical sources (eg, air, bedding, food, water). Toxicologic pathologists should remember that some differences in responsiveness to a test article may reflect subtle differences in individual exposomes of seemingly equivalent test animals. Translation of toxicity data obtained in tests of genetically inbred animals maintained under controlled environmental conditions to produce quasi-identical exposomes at best offers only approximate guidance regarding potential responses in genetically heterogeneous human populations who live in many environmental settings and thus have divergent, complex exposomes.

Original languageEnglish (US)
Pages (from-to)718-720
Number of pages3
JournalToxicologic Pathology
Volume48
Issue number6
DOIs
StatePublished - Aug 1 2020

Keywords

  • adverse outcome pathways
  • chemical mixtures
  • exposome
  • review

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Toxicology
  • Cell Biology

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