Abstract
Porcine herpesvirus 1 (PHV-1) antigens were extracted from virus-infected cells using the nonionic detergent Triton X-100. A single vaccination with these viral antigens in Freund's incomplete adjuvant resulted in the production of neutralizing antibody and a cellular immune response in mice. An 87% rate of protection was observed in these mice upon challenge with a lethal dose of PHV-1. A second vaccination given at day 21 resulted in higher levels of neutrilizing antibody and 100% protection of vaccinated mice upon challenge with virulent PHV-1.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 291-299 |
| Number of pages | 9 |
| Journal | Veterinary Microbiology |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1980 |
| Externally published | Yes |
ASJC Scopus subject areas
- Microbiology
- General Veterinary