The evaluation of an experimental porcine herpesvirus 1 (Aujeszky's disease virus) subunit vaccine in mice

Daniel L Rock, D. E. Reed

Research output: Contribution to journalArticle

Abstract

Porcine herpesvirus 1 (PHV-1) antigens were extracted from virus-infected cells using the nonionic detergent Triton X-100. A single vaccination with these viral antigens in Freund's incomplete adjuvant resulted in the production of neutralizing antibody and a cellular immune response in mice. An 87% rate of protection was observed in these mice upon challenge with a lethal dose of PHV-1. A second vaccination given at day 21 resulted in higher levels of neutrilizing antibody and 100% protection of vaccinated mice upon challenge with virulent PHV-1.

Original languageEnglish (US)
Pages (from-to)291-299
Number of pages9
JournalVeterinary Microbiology
Volume5
Issue number4
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

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Suid Herpesvirus 1
Subunit Vaccines
Suid herpesvirus 1
subunit vaccines
mice
Vaccination
vaccination
Viral Antigens
viral antigens
lethal dose
Octoxynol
Neutralizing Antibodies
neutralizing antibodies
Cellular Immunity
detergents
cell-mediated immunity
Detergents
adjuvants
Viruses
antigens

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)

Cite this

The evaluation of an experimental porcine herpesvirus 1 (Aujeszky's disease virus) subunit vaccine in mice. / Rock, Daniel L; Reed, D. E.

In: Veterinary Microbiology, Vol. 5, No. 4, 01.01.1980, p. 291-299.

Research output: Contribution to journalArticle

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