TY - JOUR
T1 - The epigenetic impacts of endocrine disruptors on female reproduction across generations
AU - Rattan, Saniya
AU - Flaws, Jodi A.
N1 - ∗Correspondence: Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, 2001 S. Lincoln Ave. Tel: +217-333-7933; E-mail: [email protected] †Grant Support: This work was supported by the Billie A. Field Fellowship in Reproductive Biology (SR), NIH P01 ES022848 (JAF), EPA RD83 543401 (JAF), NIH F31 ES030467 (SR), and NIH T32 ES007326 (SR). Edited by Dr. Lane K. Christenson, PhD, University of Kansas Medical Center
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Humans and animals are repeatedly exposed to endocrine disruptors, many of which are ubiquitous in the environment. Endocrine disruptors interfere with hormone action; thus, causing non-monotonic dose responses that are atypical of standard toxicant exposures. The female reproductive system is particularly susceptible to the effects of endocrine disruptors. Likewise, exposures to endocrine disruptors during developmental periods are particularly concerning because programming during development can be adversely impacted by hormone level changes. Subsequently, developing reproductive tissues can be predisposed to diseases in adulthood and these diseases can be passed down to future generations. The mechanisms of action by which endocrine disruptors cause disease transmission to future generations are thought to include epigenetic modifications. This review highlights the effects of endocrine disruptors on the female reproductive system, with an emphasis on the multi-and transgenerational epigenetic effects of these exposures.
AB - Humans and animals are repeatedly exposed to endocrine disruptors, many of which are ubiquitous in the environment. Endocrine disruptors interfere with hormone action; thus, causing non-monotonic dose responses that are atypical of standard toxicant exposures. The female reproductive system is particularly susceptible to the effects of endocrine disruptors. Likewise, exposures to endocrine disruptors during developmental periods are particularly concerning because programming during development can be adversely impacted by hormone level changes. Subsequently, developing reproductive tissues can be predisposed to diseases in adulthood and these diseases can be passed down to future generations. The mechanisms of action by which endocrine disruptors cause disease transmission to future generations are thought to include epigenetic modifications. This review highlights the effects of endocrine disruptors on the female reproductive system, with an emphasis on the multi-and transgenerational epigenetic effects of these exposures.
KW - DNA methylation
KW - chromatin
KW - developmental origins of health and disease
KW - endocrine disruptors
KW - environmental contaminants and toxicants
KW - epigenetics
KW - female reproductive tract
KW - histone modifications
UR - http://www.scopus.com/inward/record.url?scp=85067931524&partnerID=8YFLogxK
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U2 - 10.1093/biolre/ioz081
DO - 10.1093/biolre/ioz081
M3 - Review article
C2 - 31077281
AN - SCOPUS:85067931524
SN - 0006-3363
VL - 101
SP - 635
EP - 644
JO - Biology of reproduction
JF - Biology of reproduction
IS - 3
ER -