The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort

Environmental influences on Child Health Outcomes

doi:10.1093/aje/kwad071

The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort

Environmental influences on Child Health Outcomes

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Abstract

The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of Health (NIH) in 2016 to improve children’s health in the United States. The EWC harmonizes extant data and collects new data using a standardized protocol, the ECHO-Wide Cohort Data Collection Protocol (EWCP). EWCP visits occur at least once per life stage, but the frequency and timing of the visits vary across cohorts. As of March 4, 2022, the EWC cohorts contributed data from 60,553 children and consented 29,622 children for new EWCP data and biospecimen collection. The median (interquartile range) age of EWCP-enrolled children was 7.5 years (3.7–11.1). Surveys, interviews, standardized examinations, laboratory analyses, and medical record abstraction are used to obtain information in 5 main outcome areas: pre-, peri-, and postnatal outcomes; neurodevelopment; obesity; airways; and positive health. Exposures include factors at the level of place (e.g., air pollution, neighborhood socioeconomic status), family (e.g., parental mental health), and individuals (e.g., diet, genomics).

Original language	English (US)
Pages (from-to)	1249-1263
Number of pages	15
Journal	American Journal of Epidemiology
Volume	192
Issue number	8
Early online date	Mar 24 2023
DOIs	https://doi.org/10.1093/aje/kwad071
State	Published - Aug 1 2023

Keywords

adolescent
child
child development
child health
child well-being
cohort studies
environmental exposure
epidemiologic methods

ASJC Scopus subject areas

General Medicine

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10.1093/aje/kwad071License: CC BY-NC

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@article{214d7a53d90c4202adc467f2f60e1179,

title = "The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort",

abstract = "The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of Health (NIH) in 2016 to improve children{\textquoteright}s health in the United States. The EWC harmonizes extant data and collects new data using a standardized protocol, the ECHO-Wide Cohort Data Collection Protocol (EWCP). EWCP visits occur at least once per life stage, but the frequency and timing of the visits vary across cohorts. As of March 4, 2022, the EWC cohorts contributed data from 60,553 children and consented 29,622 children for new EWCP data and biospecimen collection. The median (interquartile range) age of EWCP-enrolled children was 7.5 years (3.7–11.1). Surveys, interviews, standardized examinations, laboratory analyses, and medical record abstraction are used to obtain information in 5 main outcome areas: pre-, peri-, and postnatal outcomes; neurodevelopment; obesity; airways; and positive health. Exposures include factors at the level of place (e.g., air pollution, neighborhood socioeconomic status), family (e.g., parental mental health), and individuals (e.g., diet, genomics).",

keywords = "adolescent, child, child development, child health, child well-being, cohort studies, environmental exposure, epidemiologic methods",

author = "{Environmental influences on Child Health Outcomes} and Knapp, {Emily A.} and Kress, {Amii M.} and Parker, {Corette B.} and Page, {Grier P.} and Kristen McArthur and Gachigi, {Kennedy K.} and Alshawabkeh, {Akram N.} and Aschner, {Judy L.} and Bastain, {Theresa M.} and Breton, {Carrie V.} and Bendixsen, {Casper G.} and Brennan, {Patricia A.} and Bush, {Nicole R.} and Claudia Buss and Camargo, {Carlos A.} and Diane Catellier and Cordero, {Jos{\'e} F.} and Lisa Croen and Dana Dabelea and Sean Deoni and Viren D{\textquoteright}Sa and Duarte, {Cristiane S.} and Dunlop, {Anne L.} and Elliott, {Amy J.} and Farzan, {Shohreh F.} and Assiamira Ferrara and Ganiban, {Jody M.} and Gern, {James E.} and Giardino, {Angelo P.} and Towe-Goodman, {Nissa R.} and Gold, {Diane R.} and Rima Habre and Hamra, {Ghassan B.} and Tina Hartert and Herbstman, {Julie B.} and Irva Hertz-Picciotto and Hipwell, {Alison E.} and Karagas, {Margaret R.} and Karr, {Catherine J.} and Kate Keenan and Kerver, {Jean M.} and Daphne Koinis-Mitchell and Bryan Lau and Lester, {Barry M.} and Leve, {Leslie D.} and Bennett Leventhal and LeWinn, {Kaja Z.} and Johnnye Lewis and Litonjua, {Augusto A.} and Schantz, {Susan L.}",

note = "Research reported in this publication was supported by the Environmental Influences on Child Health Outcomes (ECHO) program, Office of the Director, National Institutes of Health, under award numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 with co-funding from the Office of Behavioral and Social Science Research (PROCore), U24ES026539 (HHEAR O{\textquoteright}Brien), U2CES026533 (HHEAR Peterson), U2CES026542 (HHEAR Parsons, Kannan), U2CES030859 (Arora), U2CES030857 (HHEAR Fennell, Sumner, Du), U2CES026555 (HHEAR Teitelbaum), U2CES026561 (HHEAR Wright), U2CES030851 (HHEAR Stapleton, Ferguson), and UH3OD023251 (A.N.A.), UH3OD023320 (J.L.A.), UH3OD023332 (L.T.), UH3OD023253 (C.A.C.), UH3OD023248 (D.D), UH3OD023313 (D.K.M.), UH3OD023328 (C.S.D.), UH3OD023318 (A.L.D.), UH3OD023279 (A.J.E.), UH3OD023289 (A.F.), UH3OD023282 (J.E.G.), UH3OD023287 (C.V.B.), UH3OD023365 (I.H.P.), UH3OD023244 (A.E.H.), UH3OD023275 (M.R.K.), UH3OD023271 (C.J.K.), UH3OD023347 (B.M.L.), UH3OD023389 (L.D.L.), UH3OD023344 (MacKenzie), UH3OD023268 (S.T.W.), UH3OD023288 (C.T.M.), UH3OD023342 (K.L.), UH3OD023349 (T.G.O.C.), UH3OD023286 (E.O.), UH3OD023348 (M.O.S.), UH3OD023285 (J.M.K.), UH3OD023290 (J.B.H.), UH3OD023272 (S.L.S.), UH3OD023249 (J.B.S.), UH3OD023305 (L.T), UH3OD023337 (R.J.W.). Deidentified data from the ECHO Program are available through NICHD{\textquoteright}s Data and Specimen Hub (DASH), https://dash.nichd.nih.gov/. DASH is a centralized resource that allows researchers to access data from various studies via a controlled-access mechanism. Researchers can now request access to these data by creating a DASH account and submitting a Data Request Form. The NICHD DASH Data Access Committee will review the request and provide a response in approximately two to three weeks. Once granted access, researchers will be able to use the data for three years. See the DASH Tutorial for more detailed information on the process. The authors thank our ECHO colleagues; the medical, nursing, and program staff; and the children and families participating in the ECHO cohorts. We also thank Andrew Law, Janet Moore, and Tim Shields for the creation of the manuscript figures, and Jonathan Lewis, Xiuhong Li, Zone Li, Morgan Nelson, Melanie Kelly, and Brooke Walker for their assistance preparing this manuscript. We also acknowledge the contribution of additional ECHO program collaborators in additional acknowledgements in the Web Material. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Conflict of interest: J.E.G. has served as a consultant to Astra/Zeneca and Meissa Vaccines Inc, has stock options in Meissa Vaccines Inc, and has patents related to rhinovirus production methods. A.A.L. receives royalties from UpToDate, Inc. S.T.W. receives royalties from UpToDate and is on the Board of Histolix, a digital pathology company. The other authors report no conflicts. Research reported in this publication was supported by the Environmental Influences on Child Health Outcomes (ECHO) program, Office of the Director, National Institutes of Health, under award numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 with co-funding from the Office of Behavioral and Social Science Research (PROCore), U24ES026539 (HHEAR O{\textquoteright}Brien), U2CES026533 (HHEAR Peterson), U2CES026542 (HHEAR Parsons, Kannan), U2CES030859 (Arora), U2CES030857 (HHEAR Fennell, Sumner, Du), U2CES026555 (HHEAR Teitelbaum), U2CES026561 (HHEAR Wright), U2CES030851 (HHEAR Stapleton, Ferguson), and UH3OD023251 (A.N.A.), UH3OD023320 (J.L.A.), UH3OD023332 (L.T.), UH3OD023253 (C.A.C.), UH3OD023248 (D.D), UH3OD023313 (D.K.M.), UH3OD023328 (C.S.D.), UH3OD023318 (A.L.D.), UH3OD023279 (A.J.E.), UH3OD023289 (A.F.), UH3OD023282 (J.E.G.), UH3OD023287 (C.V.B.), UH3OD023365 (I.H.P.), UH3OD023244 (A.E.H.), UH3OD023275 (M.R.K.), UH3OD023271 (C.J.K.), UH3OD023347 (B.M.L.), UH3OD023389 (L.D.L.), UH3OD023344 (MacKenzie), UH3OD023268 (S.T.W.), UH3OD023288 (C.T.M.), UH3OD023342 (K.L.), UH3OD023349 (T.G.O.C.), UH3OD023286 (E.O.), UH3OD023348 (M.O.S.), UH3OD023285 (J.M.K.), UH3OD023290 (J.B.H.), UH3OD023272 (S.L.S.), UH3OD023249 (J.B.S.), UH3OD023305 (L.T), UH3OD023337 (R.J.W.).",

year = "2023",

month = aug,

day = "1",

doi = "10.1093/aje/kwad071",

language = "English (US)",

volume = "192",

pages = "1249--1263",

journal = "American Journal of Epidemiology",

issn = "0002-9262",

publisher = "Oxford University Press",

number = "8",

}

TY - JOUR

T1 - The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort

AU - Environmental influences on Child Health Outcomes

AU - Knapp, Emily A.

AU - Kress, Amii M.

AU - Parker, Corette B.

AU - Page, Grier P.

AU - McArthur, Kristen

AU - Gachigi, Kennedy K.

AU - Alshawabkeh, Akram N.

AU - Aschner, Judy L.

AU - Bastain, Theresa M.

AU - Breton, Carrie V.

AU - Bendixsen, Casper G.

AU - Brennan, Patricia A.

AU - Bush, Nicole R.

AU - Buss, Claudia

AU - Camargo, Carlos A.

AU - Catellier, Diane

AU - Cordero, José F.

AU - Croen, Lisa

AU - Dabelea, Dana

AU - Deoni, Sean

AU - D’Sa, Viren

AU - Duarte, Cristiane S.

AU - Dunlop, Anne L.

AU - Elliott, Amy J.

AU - Farzan, Shohreh F.

AU - Ferrara, Assiamira

AU - Ganiban, Jody M.

AU - Gern, James E.

AU - Giardino, Angelo P.

AU - Towe-Goodman, Nissa R.

AU - Gold, Diane R.

AU - Habre, Rima

AU - Hamra, Ghassan B.

AU - Hartert, Tina

AU - Herbstman, Julie B.

AU - Hertz-Picciotto, Irva

AU - Hipwell, Alison E.

AU - Karagas, Margaret R.

AU - Karr, Catherine J.

AU - Keenan, Kate

AU - Kerver, Jean M.

AU - Koinis-Mitchell, Daphne

AU - Lau, Bryan

AU - Lester, Barry M.

AU - Leve, Leslie D.

AU - Leventhal, Bennett

AU - LeWinn, Kaja Z.

AU - Lewis, Johnnye

AU - Litonjua, Augusto A.

AU - Schantz, Susan L.

N1 - Research reported in this publication was supported by the Environmental Influences on Child Health Outcomes (ECHO) program, Office of the Director, National Institutes of Health, under award numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 with co-funding from the Office of Behavioral and Social Science Research (PROCore), U24ES026539 (HHEAR O’Brien), U2CES026533 (HHEAR Peterson), U2CES026542 (HHEAR Parsons, Kannan), U2CES030859 (Arora), U2CES030857 (HHEAR Fennell, Sumner, Du), U2CES026555 (HHEAR Teitelbaum), U2CES026561 (HHEAR Wright), U2CES030851 (HHEAR Stapleton, Ferguson), and UH3OD023251 (A.N.A.), UH3OD023320 (J.L.A.), UH3OD023332 (L.T.), UH3OD023253 (C.A.C.), UH3OD023248 (D.D), UH3OD023313 (D.K.M.), UH3OD023328 (C.S.D.), UH3OD023318 (A.L.D.), UH3OD023279 (A.J.E.), UH3OD023289 (A.F.), UH3OD023282 (J.E.G.), UH3OD023287 (C.V.B.), UH3OD023365 (I.H.P.), UH3OD023244 (A.E.H.), UH3OD023275 (M.R.K.), UH3OD023271 (C.J.K.), UH3OD023347 (B.M.L.), UH3OD023389 (L.D.L.), UH3OD023344 (MacKenzie), UH3OD023268 (S.T.W.), UH3OD023288 (C.T.M.), UH3OD023342 (K.L.), UH3OD023349 (T.G.O.C.), UH3OD023286 (E.O.), UH3OD023348 (M.O.S.), UH3OD023285 (J.M.K.), UH3OD023290 (J.B.H.), UH3OD023272 (S.L.S.), UH3OD023249 (J.B.S.), UH3OD023305 (L.T), UH3OD023337 (R.J.W.). Deidentified data from the ECHO Program are available through NICHD’s Data and Specimen Hub (DASH), https://dash.nichd.nih.gov/. DASH is a centralized resource that allows researchers to access data from various studies via a controlled-access mechanism. Researchers can now request access to these data by creating a DASH account and submitting a Data Request Form. The NICHD DASH Data Access Committee will review the request and provide a response in approximately two to three weeks. Once granted access, researchers will be able to use the data for three years. See the DASH Tutorial for more detailed information on the process. The authors thank our ECHO colleagues; the medical, nursing, and program staff; and the children and families participating in the ECHO cohorts. We also thank Andrew Law, Janet Moore, and Tim Shields for the creation of the manuscript figures, and Jonathan Lewis, Xiuhong Li, Zone Li, Morgan Nelson, Melanie Kelly, and Brooke Walker for their assistance preparing this manuscript. We also acknowledge the contribution of additional ECHO program collaborators in additional acknowledgements in the Web Material. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Conflict of interest: J.E.G. has served as a consultant to Astra/Zeneca and Meissa Vaccines Inc, has stock options in Meissa Vaccines Inc, and has patents related to rhinovirus production methods. A.A.L. receives royalties from UpToDate, Inc. S.T.W. receives royalties from UpToDate and is on the Board of Histolix, a digital pathology company. The other authors report no conflicts. Research reported in this publication was supported by the Environmental Influences on Child Health Outcomes (ECHO) program, Office of the Director, National Institutes of Health, under award numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 with co-funding from the Office of Behavioral and Social Science Research (PROCore), U24ES026539 (HHEAR O’Brien), U2CES026533 (HHEAR Peterson), U2CES026542 (HHEAR Parsons, Kannan), U2CES030859 (Arora), U2CES030857 (HHEAR Fennell, Sumner, Du), U2CES026555 (HHEAR Teitelbaum), U2CES026561 (HHEAR Wright), U2CES030851 (HHEAR Stapleton, Ferguson), and UH3OD023251 (A.N.A.), UH3OD023320 (J.L.A.), UH3OD023332 (L.T.), UH3OD023253 (C.A.C.), UH3OD023248 (D.D), UH3OD023313 (D.K.M.), UH3OD023328 (C.S.D.), UH3OD023318 (A.L.D.), UH3OD023279 (A.J.E.), UH3OD023289 (A.F.), UH3OD023282 (J.E.G.), UH3OD023287 (C.V.B.), UH3OD023365 (I.H.P.), UH3OD023244 (A.E.H.), UH3OD023275 (M.R.K.), UH3OD023271 (C.J.K.), UH3OD023347 (B.M.L.), UH3OD023389 (L.D.L.), UH3OD023344 (MacKenzie), UH3OD023268 (S.T.W.), UH3OD023288 (C.T.M.), UH3OD023342 (K.L.), UH3OD023349 (T.G.O.C.), UH3OD023286 (E.O.), UH3OD023348 (M.O.S.), UH3OD023285 (J.M.K.), UH3OD023290 (J.B.H.), UH3OD023272 (S.L.S.), UH3OD023249 (J.B.S.), UH3OD023305 (L.T), UH3OD023337 (R.J.W.).

PY - 2023/8/1

Y1 - 2023/8/1

N2 - The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of Health (NIH) in 2016 to improve children’s health in the United States. The EWC harmonizes extant data and collects new data using a standardized protocol, the ECHO-Wide Cohort Data Collection Protocol (EWCP). EWCP visits occur at least once per life stage, but the frequency and timing of the visits vary across cohorts. As of March 4, 2022, the EWC cohorts contributed data from 60,553 children and consented 29,622 children for new EWCP data and biospecimen collection. The median (interquartile range) age of EWCP-enrolled children was 7.5 years (3.7–11.1). Surveys, interviews, standardized examinations, laboratory analyses, and medical record abstraction are used to obtain information in 5 main outcome areas: pre-, peri-, and postnatal outcomes; neurodevelopment; obesity; airways; and positive health. Exposures include factors at the level of place (e.g., air pollution, neighborhood socioeconomic status), family (e.g., parental mental health), and individuals (e.g., diet, genomics).

AB - The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of Health (NIH) in 2016 to improve children’s health in the United States. The EWC harmonizes extant data and collects new data using a standardized protocol, the ECHO-Wide Cohort Data Collection Protocol (EWCP). EWCP visits occur at least once per life stage, but the frequency and timing of the visits vary across cohorts. As of March 4, 2022, the EWC cohorts contributed data from 60,553 children and consented 29,622 children for new EWCP data and biospecimen collection. The median (interquartile range) age of EWCP-enrolled children was 7.5 years (3.7–11.1). Surveys, interviews, standardized examinations, laboratory analyses, and medical record abstraction are used to obtain information in 5 main outcome areas: pre-, peri-, and postnatal outcomes; neurodevelopment; obesity; airways; and positive health. Exposures include factors at the level of place (e.g., air pollution, neighborhood socioeconomic status), family (e.g., parental mental health), and individuals (e.g., diet, genomics).

KW - adolescent

KW - child

KW - child development

KW - child health

KW - child well-being

KW - cohort studies

KW - environmental exposure

KW - epidemiologic methods

UR - http://www.scopus.com/inward/record.url?scp=85158077753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85158077753&partnerID=8YFLogxK

U2 - 10.1093/aje/kwad071

DO - 10.1093/aje/kwad071

M3 - Article

C2 - 36963379

AN - SCOPUS:85158077753

SN - 0002-9262

VL - 192

SP - 1249

EP - 1263

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

IS - 8

ER -

The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort

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