The effects of the phytoestrogen, coumestrol, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 GnRH neurones

J. Bowe; Xiao Feng Li; D. Sugden; J. A. Katzenellenbogen; B. S. Katzenellenbogen; K. T. O'Byrne

doi:10.1046/j.1365-2826.2003.00991.x

The effects of the phytoestrogen, coumestrol, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 GnRH neurones

J. Bowe, Xiao Feng Li, D. Sugden, J. A. Katzenellenbogen, B. S. Katzenellenbogen, K. T. O'Byrne

Research output: Contribution to journal › Article › peer-review

Abstract

Phytoestrogens can produce inhibitory effects on gonadotropin secretion in both animals and humans, although little is known about the mechanisms and the role of direct action on oestrogen receptors (ER) in this process. We examined the effect of coumestrol, alone and combined with ER antagonists, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 cells. Coumestrol was found to have an inhibitory effect compared to controls, which was blocked by R,R-THC, a selective ERβ antagonist. These results suggest that ERβ is involved in the suppression of GnRH mRNA expression by coumestrol.

Original language	English (US)
Pages (from-to)	105-108
Number of pages	4
Journal	Journal of Neuroendocrinology
Volume	15
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2826.2003.00991.x
State	Published - Feb 1 2003

Keywords

Coumestrol
GT1-7
Gonadotropin-releasing hormone
Oestrogen

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

Online availability

10.1046/j.1365-2826.2003.00991.x

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abstract = "Phytoestrogens can produce inhibitory effects on gonadotropin secretion in both animals and humans, although little is known about the mechanisms and the role of direct action on oestrogen receptors (ER) in this process. We examined the effect of coumestrol, alone and combined with ER antagonists, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 cells. Coumestrol was found to have an inhibitory effect compared to controls, which was blocked by R,R-THC, a selective ERβ antagonist. These results suggest that ERβ is involved in the suppression of GnRH mRNA expression by coumestrol.",

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AU - Li, Xiao Feng

AU - Sugden, D.

AU - Katzenellenbogen, J. A.

AU - Katzenellenbogen, B. S.

AU - O'Byrne, K. T.

PY - 2003/2/1

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AB - Phytoestrogens can produce inhibitory effects on gonadotropin secretion in both animals and humans, although little is known about the mechanisms and the role of direct action on oestrogen receptors (ER) in this process. We examined the effect of coumestrol, alone and combined with ER antagonists, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 cells. Coumestrol was found to have an inhibitory effect compared to controls, which was blocked by R,R-THC, a selective ERβ antagonist. These results suggest that ERβ is involved in the suppression of GnRH mRNA expression by coumestrol.

KW - Coumestrol

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The effects of the phytoestrogen, coumestrol, on gonadotropin-releasing hormone (GnRH) mRNA expression in GT1-7 GnRH neurones

Abstract

Keywords

ASJC Scopus subject areas

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