TY - JOUR
T1 - The Effects of Environmental Contaminant Exposure on Reproductive Aging and the Menopause Transition
AU - Neff, Alison M.
AU - Laws, Mary J.
AU - Warner, Genoa R.
AU - Flaws, Jodi A.
N1 - Funding Information:
This work was supported by National Institutes of Health grants T32 ES007326, R01 ES030206, R01 ES028661, and K99 ES031150.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2022/3
Y1 - 2022/3
N2 - Purpose of Review: Menopause marks the end of a woman’s reproductive lifetime. On average, natural menopause occurs at 51 years of age. However, some women report an earlier age of menopause than the national average. This can be problematic for women who delay starting a family. Moreover, early onset of menopause is associated with increased risk of cardiovascular disease, depression, osteoporosis, and premature death. This review investigates associations between exposure to endocrine-disrupting chemicals (EDCs) and earlier onset of menopause. Recent Findings: Recent data suggest exposure to certain EDCs may accelerate reproductive aging and contribute to earlier onset of menopause. Summary: Human and rodent-based studies identify positive associations between exposure to certain EDCs/environmental contaminants and reproductive aging, earlier onset of menopause, and occurrence of vasomotor symptoms. These findings increase our understanding of the detrimental effects of EDCs on female reproduction and will help lead to the development of strategies for the treatment/prevention of EDC-induced reproductive aging.
AB - Purpose of Review: Menopause marks the end of a woman’s reproductive lifetime. On average, natural menopause occurs at 51 years of age. However, some women report an earlier age of menopause than the national average. This can be problematic for women who delay starting a family. Moreover, early onset of menopause is associated with increased risk of cardiovascular disease, depression, osteoporosis, and premature death. This review investigates associations between exposure to endocrine-disrupting chemicals (EDCs) and earlier onset of menopause. Recent Findings: Recent data suggest exposure to certain EDCs may accelerate reproductive aging and contribute to earlier onset of menopause. Summary: Human and rodent-based studies identify positive associations between exposure to certain EDCs/environmental contaminants and reproductive aging, earlier onset of menopause, and occurrence of vasomotor symptoms. These findings increase our understanding of the detrimental effects of EDCs on female reproduction and will help lead to the development of strategies for the treatment/prevention of EDC-induced reproductive aging.
KW - Endocrine-disrupting chemicals
KW - Menopause
KW - Ovary
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U2 - 10.1007/s40572-022-00334-y
DO - 10.1007/s40572-022-00334-y
M3 - Review article
C2 - 35103957
AN - SCOPUS:85123992956
SN - 2196-5412
VL - 9
SP - 53
EP - 79
JO - Current environmental health reports
JF - Current environmental health reports
IS - 1
ER -