TY - JOUR
T1 - The effects of doxapram hydrochloride (dopram-V) on laryngeal function in healthy dogs
AU - Miller, Carrie Jean
AU - McKiernan, Brendan C.
AU - Pace, Jennifer
AU - Fettman, Martin J.
PY - 2002
Y1 - 2002
N2 - Laryngeal dysfunction is assessed most accurately by direct visualization of the larynx under a light plane of anesthesia. If the plane of anesthesia used is too deep, laryngeal structures may appear paralyzed and remain in a paramedian position. Doxapram hydrochloride is a known respiratory stimulant. We hypothesized that doxapram would significantly increase intrinsic laryngeal motion in healthy anesthetized dogs. The goal of this study was to evaluate the effect of doxapram on the area of rima glottidis (RG) in healthy dogs. Thirty healthy dogs were studied. Dogs were premedicated with hutorphanol tartrate (0.22 mg/kg IV), acepromazine maleate (0.05 mg/kg SC). and glycopyrrolate (0.005 mg/kg SC), followed by induction with propofol (4 mg/kg IV). Intrinsic laryngeal motion observed in each dog was recorded on videotape after induction. Doxapram then was administered (2.2 mg/kg IV) and respirations again were recorded Representative breaths for each dog were photographed during 4 phases of respiration (inspiration at rest, inspiration with doxapram. expiration at rest, and expiration with doxapram) The area of the RG then was calculated by using a computer-assisted analysis program. Results of each category were compared by using a 1-way analysis of variance; P ≤ .05 was considered significant Doxapram visibly increased respiratory effort, and was associated with increased intrinsic laryngeal motion. Compared to the resting state, the area of the RG was significantly increased after doxapram administration during both inspiration and expiration. We propose the routine use of doxapram during laryngoscopy to increase intrinsic laryngeal motion and aid in the diagnosis of laryngeal dysfunction.
AB - Laryngeal dysfunction is assessed most accurately by direct visualization of the larynx under a light plane of anesthesia. If the plane of anesthesia used is too deep, laryngeal structures may appear paralyzed and remain in a paramedian position. Doxapram hydrochloride is a known respiratory stimulant. We hypothesized that doxapram would significantly increase intrinsic laryngeal motion in healthy anesthetized dogs. The goal of this study was to evaluate the effect of doxapram on the area of rima glottidis (RG) in healthy dogs. Thirty healthy dogs were studied. Dogs were premedicated with hutorphanol tartrate (0.22 mg/kg IV), acepromazine maleate (0.05 mg/kg SC). and glycopyrrolate (0.005 mg/kg SC), followed by induction with propofol (4 mg/kg IV). Intrinsic laryngeal motion observed in each dog was recorded on videotape after induction. Doxapram then was administered (2.2 mg/kg IV) and respirations again were recorded Representative breaths for each dog were photographed during 4 phases of respiration (inspiration at rest, inspiration with doxapram. expiration at rest, and expiration with doxapram) The area of the RG then was calculated by using a computer-assisted analysis program. Results of each category were compared by using a 1-way analysis of variance; P ≤ .05 was considered significant Doxapram visibly increased respiratory effort, and was associated with increased intrinsic laryngeal motion. Compared to the resting state, the area of the RG was significantly increased after doxapram administration during both inspiration and expiration. We propose the routine use of doxapram during laryngoscopy to increase intrinsic laryngeal motion and aid in the diagnosis of laryngeal dysfunction.
KW - Laryngeal evaluation
KW - Laryngeal paralysis, Laryngoscopy
KW - Respiratory stimulants
KW - Rima glottidis
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U2 - 10.1111/j.1939-1676.2002.tb02381.x
DO - 10.1111/j.1939-1676.2002.tb02381.x
M3 - Article
C2 - 12322700
AN - SCOPUS:1042297059
SN - 0891-6640
VL - 16
SP - 524
EP - 528
JO - Journal of veterinary internal medicine
JF - Journal of veterinary internal medicine
IS - 5
ER -