The effects of dietary levels of genistein on ovarian follicle number and gene expression

Payel Kundu; Shreya Patel; Daryl D. Meling; Kassie Deal; Liying Gao; William G. Helferich; Jodi A. Flaws

doi:10.1016/j.reprotox.2018.07.085

The effects of dietary levels of genistein on ovarian follicle number and gene expression

Payel Kundu, Shreya Patel, Daryl D. Meling, Kassie Deal, Liying Gao, William G. Helferich, Jodi A. Flaws

Research output: Contribution to journal › Article › peer-review

Abstract

Genistein is a phytoestrogen found in soy. We previously found that adult exposure to dietary levels of genistein affected gestation time, parturition time, litter size, pup weight, and pup mortality in CD-1 mice. The present study investigated the effects of adult genistein exposure on follicle number and gene expression in the ovaries of CD-1 mice. We found that exposure to genistein had no effect on follicle number, but it did affect the expression of apoptotic regulatory genes (Bax, Bcl-2, Bid, and Dffa) in the ovary.

Original language	English (US)
Pages (from-to)	132-139
Number of pages	8
Journal	Reproductive Toxicology
Volume	81
DOIs	https://doi.org/10.1016/j.reprotox.2018.07.085
State	Published - Oct 2018

Keywords

Follicles
Gene expression
Genistein
Ovary

ASJC Scopus subject areas

Toxicology

Online availability

10.1016/j.reprotox.2018.07.085

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title = "The effects of dietary levels of genistein on ovarian follicle number and gene expression",

abstract = "Genistein is a phytoestrogen found in soy. We previously found that adult exposure to dietary levels of genistein affected gestation time, parturition time, litter size, pup weight, and pup mortality in CD-1 mice. The present study investigated the effects of adult genistein exposure on follicle number and gene expression in the ovaries of CD-1 mice. We found that exposure to genistein had no effect on follicle number, but it did affect the expression of apoptotic regulatory genes (Bax, Bcl-2, Bid, and Dffa) in the ovary.",

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year = "2018",

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doi = "10.1016/j.reprotox.2018.07.085",

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AU - Kundu, Payel

AU - Patel, Shreya

AU - Meling, Daryl D.

AU - Deal, Kassie

AU - Gao, Liying

AU - Helferich, William G.

AU - Flaws, Jodi A.

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Y1 - 2018/10

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AB - Genistein is a phytoestrogen found in soy. We previously found that adult exposure to dietary levels of genistein affected gestation time, parturition time, litter size, pup weight, and pup mortality in CD-1 mice. The present study investigated the effects of adult genistein exposure on follicle number and gene expression in the ovaries of CD-1 mice. We found that exposure to genistein had no effect on follicle number, but it did affect the expression of apoptotic regulatory genes (Bax, Bcl-2, Bid, and Dffa) in the ovary.

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KW - Gene expression

KW - Genistein

KW - Ovary

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The effects of dietary levels of genistein on ovarian follicle number and gene expression

Abstract

Keywords

ASJC Scopus subject areas

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