The effects of dietary levels of genistein on ovarian follicle number and gene expression

Payel Kundu, Shreya Patel, Daryl D. Meling, Kassie Deal, Liying Gao, William G. Helferich, Jodi A. Flaws

Research output: Contribution to journalArticle

Abstract

Genistein is a phytoestrogen found in soy. We previously found that adult exposure to dietary levels of genistein affected gestation time, parturition time, litter size, pup weight, and pup mortality in CD-1 mice. The present study investigated the effects of adult genistein exposure on follicle number and gene expression in the ovaries of CD-1 mice. We found that exposure to genistein had no effect on follicle number, but it did affect the expression of apoptotic regulatory genes (Bax, Bcl-2, Bid, and Dffa) in the ovary.

Original languageEnglish (US)
Pages (from-to)132-139
Number of pages8
JournalReproductive Toxicology
Volume81
DOIs
StatePublished - Oct 2018

Keywords

  • Follicles
  • Gene expression
  • Genistein
  • Ovary

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'The effects of dietary levels of genistein on ovarian follicle number and gene expression'. Together they form a unique fingerprint.

  • Cite this