Abstract
(matrix presented) Chiral trichlorosilyl enolates bearing a remote stereogenic center were employed in the phosphoramide-catalyzed aldol reaction. The additions of the methyl ketone enolates proceeded with only moderate diastereoselectivities. The addition of the Z-enolate to various aldehydes selectively produced the syn relative diastereomers. In both cases, the effect of the β-silyloxy stereogenic center was modest, and the internal diastereoselection was mainly controlled by the catalyst.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3477-3480 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 4 |
| Issue number | 20 |
| DOIs | |
| State | Published - Oct 3 2002 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry