Abstract
Keratoconus is an eye disorder wherein the cornea weakens due to structural and/or compositional anomalies. This weakened cornea is no longer able to preserve its normal shape against the intraocular pressure in the eye and therefore bulges outward, leading to a conical shape and subsequent distorted vision. Changes in structure and composition often manifest as a change in shape (or geometry) as well as in mechanical and optical properties. Thus, understanding the properties and structure of keratoconic corneas could help elucidate etiology and pathogenesis, to develop treatments, and to understand other diseases of the eye. In this review, we discuss the changes in structure, composition, and mechanical and optical properties of the cornea with keratoconus. Current treatments for keratoconus and a novel proposed treatment using two-photon excitation therapy are also discussed. The intended audiences are mechanical engineers, materials engineers, optical engineers, and bioengineers.
Original language | English (US) |
---|---|
Pages (from-to) | 223-236 |
Number of pages | 14 |
Journal | Journal of the Mechanical Behavior of Biomedical Materials |
Volume | 4 |
Issue number | 3 |
DOIs | |
State | Published - Apr 1 2011 |
Keywords
- Collagen cross-linking
- Keratoconus
- Mechanical properties
- Optical properties
- Second-harmonic generation imaging
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
- Mechanics of Materials