Abstract
Keratoconus is an eye disorder wherein the cornea weakens due to structural and/or compositional anomalies. This weakened cornea is no longer able to preserve its normal shape against the intraocular pressure in the eye and therefore bulges outward, leading to a conical shape and subsequent distorted vision. Changes in structure and composition often manifest as a change in shape (or geometry) as well as in mechanical and optical properties. Thus, understanding the properties and structure of keratoconic corneas could help elucidate etiology and pathogenesis, to develop treatments, and to understand other diseases of the eye. In this review, we discuss the changes in structure, composition, and mechanical and optical properties of the cornea with keratoconus. Current treatments for keratoconus and a novel proposed treatment using two-photon excitation therapy are also discussed. The intended audiences are mechanical engineers, materials engineers, optical engineers, and bioengineers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 223-236 |
| Number of pages | 14 |
| Journal | Journal of the Mechanical Behavior of Biomedical Materials |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 1 2011 |
Fingerprint
Keywords
- Collagen cross-linking
- Keratoconus
- Mechanical properties
- Optical properties
- Second-harmonic generation imaging
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
- Mechanics of Materials
Cite this
The effect of keratoconus on the structural, mechanical, and optical properties of the cornea. / Ambekar, Raghu; Toussaint, Kimani C.; Wagoner Johnson, Amy.
In: Journal of the Mechanical Behavior of Biomedical Materials, Vol. 4, No. 3, 01.04.2011, p. 223-236.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The effect of keratoconus on the structural, mechanical, and optical properties of the cornea
AU - Ambekar, Raghu
AU - Toussaint, Kimani C.
AU - Wagoner Johnson, Amy
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Keratoconus is an eye disorder wherein the cornea weakens due to structural and/or compositional anomalies. This weakened cornea is no longer able to preserve its normal shape against the intraocular pressure in the eye and therefore bulges outward, leading to a conical shape and subsequent distorted vision. Changes in structure and composition often manifest as a change in shape (or geometry) as well as in mechanical and optical properties. Thus, understanding the properties and structure of keratoconic corneas could help elucidate etiology and pathogenesis, to develop treatments, and to understand other diseases of the eye. In this review, we discuss the changes in structure, composition, and mechanical and optical properties of the cornea with keratoconus. Current treatments for keratoconus and a novel proposed treatment using two-photon excitation therapy are also discussed. The intended audiences are mechanical engineers, materials engineers, optical engineers, and bioengineers.
AB - Keratoconus is an eye disorder wherein the cornea weakens due to structural and/or compositional anomalies. This weakened cornea is no longer able to preserve its normal shape against the intraocular pressure in the eye and therefore bulges outward, leading to a conical shape and subsequent distorted vision. Changes in structure and composition often manifest as a change in shape (or geometry) as well as in mechanical and optical properties. Thus, understanding the properties and structure of keratoconic corneas could help elucidate etiology and pathogenesis, to develop treatments, and to understand other diseases of the eye. In this review, we discuss the changes in structure, composition, and mechanical and optical properties of the cornea with keratoconus. Current treatments for keratoconus and a novel proposed treatment using two-photon excitation therapy are also discussed. The intended audiences are mechanical engineers, materials engineers, optical engineers, and bioengineers.
KW - Collagen cross-linking
KW - Keratoconus
KW - Mechanical properties
KW - Optical properties
KW - Second-harmonic generation imaging
UR - http://www.scopus.com/inward/record.url?scp=79751527296&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79751527296&partnerID=8YFLogxK
U2 - 10.1016/j.jmbbm.2010.09.014
DO - 10.1016/j.jmbbm.2010.09.014
M3 - Review article
C2 - 21316609
AN - SCOPUS:79751527296
VL - 4
SP - 223
EP - 236
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
SN - 1751-6161
IS - 3
ER -