TY - JOUR
T1 - The effect of keratoconus on the structural, mechanical, and optical properties of the cornea
AU - Ambekar, Raghu
AU - Toussaint, Kimani C.
AU - Wagoner Johnson, Amy
N1 - Funding Information:
R.A. and K.C.T. acknowledge support from the University of Illinois at Urbana-Champaign (UIUC) research start-up funds. We are grateful to Dr. Samer Sayegh for his valuable suggestions and feedback, and David Luedke for his help in preparing this manuscript. This review was inspired by a class project by R.A. in a tissue mechanics course taught by A.W.J. A.W.J. is grateful for departmental support in developing this course.
PY - 2011/4
Y1 - 2011/4
N2 - Keratoconus is an eye disorder wherein the cornea weakens due to structural and/or compositional anomalies. This weakened cornea is no longer able to preserve its normal shape against the intraocular pressure in the eye and therefore bulges outward, leading to a conical shape and subsequent distorted vision. Changes in structure and composition often manifest as a change in shape (or geometry) as well as in mechanical and optical properties. Thus, understanding the properties and structure of keratoconic corneas could help elucidate etiology and pathogenesis, to develop treatments, and to understand other diseases of the eye. In this review, we discuss the changes in structure, composition, and mechanical and optical properties of the cornea with keratoconus. Current treatments for keratoconus and a novel proposed treatment using two-photon excitation therapy are also discussed. The intended audiences are mechanical engineers, materials engineers, optical engineers, and bioengineers.
AB - Keratoconus is an eye disorder wherein the cornea weakens due to structural and/or compositional anomalies. This weakened cornea is no longer able to preserve its normal shape against the intraocular pressure in the eye and therefore bulges outward, leading to a conical shape and subsequent distorted vision. Changes in structure and composition often manifest as a change in shape (or geometry) as well as in mechanical and optical properties. Thus, understanding the properties and structure of keratoconic corneas could help elucidate etiology and pathogenesis, to develop treatments, and to understand other diseases of the eye. In this review, we discuss the changes in structure, composition, and mechanical and optical properties of the cornea with keratoconus. Current treatments for keratoconus and a novel proposed treatment using two-photon excitation therapy are also discussed. The intended audiences are mechanical engineers, materials engineers, optical engineers, and bioengineers.
KW - Collagen cross-linking
KW - Keratoconus
KW - Mechanical properties
KW - Optical properties
KW - Second-harmonic generation imaging
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U2 - 10.1016/j.jmbbm.2010.09.014
DO - 10.1016/j.jmbbm.2010.09.014
M3 - Review article
C2 - 21316609
AN - SCOPUS:79751527296
VL - 4
SP - 223
EP - 236
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
SN - 1751-6161
IS - 3
ER -