The effect of intravenous fresh frozen plasma administration on fibrinogen and albumin concentrations in sick neonatal foals

A. R. Hollis, P. A. Wilkins, B. Tennent-Brown, J. E. Palmer, R. C. Boston

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigated the immediate (6 h or less) effects of fibrinogen and albumin contained in transfused equine origin fresh frozen plasma on those proteins when measured in sick neonatal foals. Fibrinogen and albumin concentrations were measured in the administered plasma and in 31 sick foals at admission to a referral neonatal intensive care unit. Additional samples were obtained from the foals at 2 and 6 h following transfusion. No changes in albumin concentration were recognised. The main determinant of fibrinogen concentration following transfusion was the concentration of fibrinogen in the foal at admission. Importantly, intravenous transfusion of equine fresh frozen plasma did not result in immediate (6 h or less) increases or decreases in the fibrinogen concentration in the recipient foals. Fibrinogen from the donor contained within transfused plasma will not directly affect fibrinogen concentrations measured at later times.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalEquine Veterinary Education
Volume28
Issue number3
DOIs
StatePublished - Mar 1 2016

Keywords

  • Acute phase protein
  • Horse
  • Inflammatory mediator
  • Neonate
  • Transfusion medicine

ASJC Scopus subject areas

  • Equine

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