The effect of intradialytic exercise on calcium, phosphorus and parathyroid hormone: a randomized controlled trial

Mohammad Ali Tabibi, Kenneth R. Wilund, Nasrin Salimian, Saghar Nikbakht, Mahsa Soleymany, Zahra Roshanaeian, Farzad Nazemi, Saghar Ahmadi

Research output: Contribution to journalArticlepeer-review


Background: Patients with kidney failure experience derangements of circulating markers of mineral metabolism and dysregulation of skeletal and cardiovascular physiology which results in high mortality rate in these patients. This study aimed to evaluate the effect of intradialytic exercise on regulation of these abnormalities in patients receiving chronic hemodialysis (HD). Methods: In this randomized controlled trial conducted in an HD center in Iran, adult patients receiving chronic HD were randomized to intradialytic exercise (60 min) in the second hour of thrice weekly dialysis for 6 months (intervention) or no intradialytic exercise (control). The primary outcomes were serum calcium, serum phosphorous and parathyroid hormone levels. Secondary outcomes were serum alkaline phosphatase and calcium-phosphorous product. Results: The study included 44 participants randomized to intervention (n = 22) or control (n = 22). During the 6-month intervention period, significant between-group changes were observed in all primary and secondary outcomes between the intervention and control groups. Statistical analyses reveal a significant increase in serum calcium (P < 0.05) as well as a significant decrease in serum phosphorous, parathyroid hormone, alkaline phosphatase and calcium-phosphorous product (P < 0.05). Conclusion: Intradialytic exercise performed for at least 60 min during thrice weekly dialysis sessions improves bone mineral metabolism in adult patients receiving HD. Further studies should focus on observing and comparing the effect of different types of exercise on bone mineral disorders and all-cause mortality in HD patients. Trial registration: Identifier: NCT04916743, Registered on 08/06/2021. Registered trial name: The Effect of Intradialytic Exercise on Calcium, Phosphorous and Parathyroid Hormone: A Randomized Controlled Trial.

Original languageEnglish (US)
Article number276
JournalBMC Nephrology
Issue number1
StatePublished - Dec 2023


  • Bone mineral disorders
  • Cardiovascular disease
  • Exercise during dialysis
  • Hematological parameters
  • Mortality

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'The effect of intradialytic exercise on calcium, phosphorus and parathyroid hormone: a randomized controlled trial'. Together they form a unique fingerprint.

Cite this