The effect of gold nanorods on cell-mediated collagen remodeling

Patrick N. Sisco; Christopher G. Wilson; Ekaterina Mironova; Sarah C. Baxter; Catherine J. Murphy; Edie C. Goldsmith

doi:10.1021/nl802142h

The effect of gold nanorods on cell-mediated collagen remodeling

Patrick N. Sisco, Christopher G. Wilson, Ekaterina Mironova, Sarah C. Baxter, Catherine J. Murphy, Edie C. Goldsmith

Research output: Contribution to journal › Article › peer-review

Abstract

Cardiac fibroblasts, the noncontractile cells of the heart, contribute to myocardial maintenance through the deposition, degradation, and organization of collagen. Adding polyelectrolyte-coated gold nanorods to three-dimensional constructs composed of collagen and cardiac fibroblasts reduced contraction and altered the expression of mRNAs encoding β-actin, α-smooth muscle actin, and collagen type 1. These data show that nanomaterials can modulate cell-mediated matrix remodeling and suggest that the targeted delivery of nanomaterials can be applied for antifibrotic therapies.

Original language	English (US)
Pages (from-to)	3409-3412
Number of pages	4
Journal	Nano letters
Volume	8
Issue number	10
DOIs	https://doi.org/10.1021/nl802142h
State	Published - Oct 2008
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl802142h

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AU - Sisco, Patrick N.

AU - Wilson, Christopher G.

AU - Mironova, Ekaterina

AU - Baxter, Sarah C.

AU - Murphy, Catherine J.

AU - Goldsmith, Edie C.

PY - 2008/10

Y1 - 2008/10

N2 - Cardiac fibroblasts, the noncontractile cells of the heart, contribute to myocardial maintenance through the deposition, degradation, and organization of collagen. Adding polyelectrolyte-coated gold nanorods to three-dimensional constructs composed of collagen and cardiac fibroblasts reduced contraction and altered the expression of mRNAs encoding β-actin, α-smooth muscle actin, and collagen type 1. These data show that nanomaterials can modulate cell-mediated matrix remodeling and suggest that the targeted delivery of nanomaterials can be applied for antifibrotic therapies.

AB - Cardiac fibroblasts, the noncontractile cells of the heart, contribute to myocardial maintenance through the deposition, degradation, and organization of collagen. Adding polyelectrolyte-coated gold nanorods to three-dimensional constructs composed of collagen and cardiac fibroblasts reduced contraction and altered the expression of mRNAs encoding β-actin, α-smooth muscle actin, and collagen type 1. These data show that nanomaterials can modulate cell-mediated matrix remodeling and suggest that the targeted delivery of nanomaterials can be applied for antifibrotic therapies.

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The effect of gold nanorods on cell-mediated collagen remodeling

Abstract

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