The effect of gold nanorods on cell-mediated collagen remodeling

Patrick N. Sisco, Christopher G. Wilson, Ekaterina Mironova, Sarah C. Baxter, Catherine J. Murphy, Edie C. Goldsmith

Research output: Contribution to journalArticlepeer-review


Cardiac fibroblasts, the noncontractile cells of the heart, contribute to myocardial maintenance through the deposition, degradation, and organization of collagen. Adding polyelectrolyte-coated gold nanorods to three-dimensional constructs composed of collagen and cardiac fibroblasts reduced contraction and altered the expression of mRNAs encoding β-actin, α-smooth muscle actin, and collagen type 1. These data show that nanomaterials can modulate cell-mediated matrix remodeling and suggest that the targeted delivery of nanomaterials can be applied for antifibrotic therapies.

Original languageEnglish (US)
Pages (from-to)3409-3412
Number of pages4
JournalNano letters
Issue number10
StatePublished - Oct 2008
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering


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