The effect of general anesthesia on canine lymphocyte function

Peter J. Felsburg, Lynette L. Keyes, Donald R. Krawiec, Stanley I. Rubin

Research output: Contribution to journalArticlepeer-review


The in vitro response of canine peripheral blood lymphocytes to mitogenic stimulation was evaluated following general anesthesia for a relatively minor diagnostic procedure. A marked suppression in the blastogenic response to phytohemagglutinin and concanavalin A was observed 4 hours postinduction which persisted through the first 24 hours and was normal by 4 days. A mild suppression to stimulation with pokeweed mitogen was observed at 4 hours postinduction but the response was back to normal by 24 hours. These results suggest general anesthesia has a transient immunosuppressive effect on canine lymphocytes and T cells are more susceptible to the immunosuppressive effect than B cells.

Original languageEnglish (US)
Pages (from-to)63-70
Number of pages8
JournalVeterinary Immunology and Immunopathology
Issue number1-2
StatePublished - Sep 1986

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)


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