The effect of acute fish-oil supplementation on endothelial function and arterial stiffness following a high-fat meal

Christopher A. Fahs, Huimin Yan, Sushant Ranadive, Lindy M. Rossow, Stamatis Agiovlasitis, Kenneth R. Wilund, Bo Fernhall

Research output: Contribution to journalArticlepeer-review

Abstract

This study examined whether a commercially available fish-oil supplement offers protection from the acute effects of a high-fat meal (HFM) on endothelial function and arterial stiffness. An HFM causes acute impairments in endothelial function, whereas the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have a variety of cardioprotective effects. However, little is known about the efficacy of moderate fish-oil supplementation on the endothelial dysfunction induced by an HFM. Endothelial function (brachial artery flow-mediated dilation (FMD)), forearm blood flow (FBF), total hyperemia, central and peripheral blood pressure, and central artery stiffness were assessed in 20 healthy men (n = 10) and women (n = 10) at rest and 4 h after an HFM supplemented with either placebo or ~ 1 g EPA and DHA. Brachial artery FMD normalized for shear rate was significantly impaired (p = 0.033) following the HFM with placebo but remained unchanged compared with baseline following the HFM with the fish-oil supplement (p = 0.039; condition × time interaction). Resting FBF (p = 0.020) and total hyperemia (p = 0.014) were elevated following the HFM. All other vascular and hemodynamic measurements were unchanged in both trials. Commercially available fish-oil supplements taken with an HFM appear to preserve endothelial function following an HFM.

Original languageEnglish (US)
Pages (from-to)294-302
Number of pages9
JournalApplied Physiology, Nutrition and Metabolism
Volume35
Issue number3
DOIs
StatePublished - Aug 6 2010

Keywords

  • Arterial stiffness
  • Endothelial function
  • Forearm blood flow
  • High-fat meal

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

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