The Detection of DNA using a Silicon Nanopore

J. B. Heng, V. Dimitrov, Y. V. Grinkova, C. Ho, T. Kim, D. Muller, Stephen Sligar, T. Sorsch, R. Twesten, R. Timp, G. Timp

Research output: Contribution to journalConference article

Abstract

We have developed a novel strategy for producing nanopores in inorganic, CMOS-compatible membranes using a tightly focused, high energy electron beam. We are able to characterize the nanopores physically (TEM, AFM) as well as electrically (ionic conductivity and "wetting" curves). Subsequently, we used the nanopore as a molecular Coulter counter to detect the size of a DNA molecule. This is the first report of the use of an inorganic nanopore for discriminating DNA molecules.

Original languageEnglish (US)
Pages (from-to)767-770
Number of pages4
JournalTechnical Digest - International Electron Devices Meeting
StatePublished - Dec 1 2003
EventIEEE International Electron Devices Meeting - Washington, DC, United States
Duration: Dec 8 2003Dec 10 2003

Fingerprint

Nanopores
Silicon
DNA
deoxyribonucleic acid
silicon
high energy electrons
ion currents
wetting
molecules
CMOS
counters
atomic force microscopy
electron beams
membranes
transmission electron microscopy
Molecules
curves
Ionic conductivity
Wetting
Electron beams

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

Heng, J. B., Dimitrov, V., Grinkova, Y. V., Ho, C., Kim, T., Muller, D., ... Timp, G. (2003). The Detection of DNA using a Silicon Nanopore. Technical Digest - International Electron Devices Meeting, 767-770.

The Detection of DNA using a Silicon Nanopore. / Heng, J. B.; Dimitrov, V.; Grinkova, Y. V.; Ho, C.; Kim, T.; Muller, D.; Sligar, Stephen; Sorsch, T.; Twesten, R.; Timp, R.; Timp, G.

In: Technical Digest - International Electron Devices Meeting, 01.12.2003, p. 767-770.

Research output: Contribution to journalConference article

Heng, JB, Dimitrov, V, Grinkova, YV, Ho, C, Kim, T, Muller, D, Sligar, S, Sorsch, T, Twesten, R, Timp, R & Timp, G 2003, 'The Detection of DNA using a Silicon Nanopore', Technical Digest - International Electron Devices Meeting, pp. 767-770.
Heng JB, Dimitrov V, Grinkova YV, Ho C, Kim T, Muller D et al. The Detection of DNA using a Silicon Nanopore. Technical Digest - International Electron Devices Meeting. 2003 Dec 1;767-770.
Heng, J. B. ; Dimitrov, V. ; Grinkova, Y. V. ; Ho, C. ; Kim, T. ; Muller, D. ; Sligar, Stephen ; Sorsch, T. ; Twesten, R. ; Timp, R. ; Timp, G. / The Detection of DNA using a Silicon Nanopore. In: Technical Digest - International Electron Devices Meeting. 2003 ; pp. 767-770.
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