In this paper we describe the data acquisition and control system of the Dark Energy Camera (DECam), which will be the primary instrument used in the Dark Energy Survey (DES). DES is a high precision multibandpath wide area survey of 5000 square degrees of the southern sky. DECam currently under construction at Fermilab will be a 3 square degree mosaic camera mounted at the prime focus of the Blanco 4m telescope at the Cerro-Tololo International Observatory (CTIO). The DECam data acquisition system (SISPI) is implemented as a distributed multi-processor system with a software architecture built on the Client-Server and Publish-Subscribe design patterns. The underlying message passing protocol is based on PYRO, a powerful distributed object technology system written entirely in Python. A distributed shared variable system was added to support exchange of telemetry data and other information between different components of the system. In this paper we discuss the SISPI infrastructure software, the image pipeline, the observer interface and quality monitoring system, and the instrument control system.