The cytochrome oxidase superfamily of redox-driven proton pumps

Melissa W. Calhoun, Jeffrey W. Thomas, Robert B. Gennis

Research output: Contribution to journalReview articlepeer-review


Most respiratory oxidases of eukaryotic and prokaryotic organisms are members of a superfamily of enzymes that couple the redox energy available from the reduction of molecular oxygen to the mechanism of pumping protons across the membrane. The recent applications of site-directed mutagenesis and of a variety of spectroscopic techniques have allowed major advances in our understanding of the structure and function of these proteins.

Original languageEnglish (US)
Pages (from-to)325-330
Number of pages6
JournalTrends in Biochemical Sciences
Issue number8
StatePublished - Aug 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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