The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus

Hans Peter Klenk, Rebecca A. Clayton, Jean Francois Tomb, Owen White, Karen E. Nelson, Karen A. Ketchum, Robert J. Dodson, Michelle Gwinn, Erin K. Hickey, Jeremy D. Peterson, Delwood L. Richardson, Anthony R. Kerlavage, David E. Graham, Nikos C. Krypides, Robert D. Fleischmann, John Quackenbush, Norman H. Lee, Granger G. Sutton, Steven Gill, Ewen F. KirknessBrian A. Dougherty, Keith McKenney, Mark D. Adams, Brendan Loftus, Scott Peterson, Claudia I. Reich, Leslie K. McNeil, Jonathan H. Badger, Anna Glodek, Lixin Zhou, Ross Overbeek, Jeannine D. Gocayne, Janice F. Wiedman, Lisa McDonald, Teresa Utterback, Matthew D. Cotton, Tracy Spriggs, Patricia Artiach, Brian P. Kaine, Sean M. Sykes, Paul W. Sadow, Kurt P. D'Andrea, Cheryl Bowman, Claire Fujii, Stacey A. Garland, Tanya M. Mason, Gary J. Olsen, Claire M. Fraser, Hamilton O. Smith, Carl R. Woese, J. Craig Venter

Research output: Contribution to journalArticle

Abstract

Archaeoglobus fulgidus is the first sulphur-metabolizing organism to have its genome sequence determined. Its genome of 2,178,400 base pairs contains 2,436 open reading frames (ORFs). The information processing systems and the biosynthetic pathways for essential components (nucleotides, amino acids and cofactors) have extensive correlation with their counterparts in the archaeon Methanococcus jannaschii. The genomes of these two Archaea indicate dramatic differences in the way these organisms sense their environment, perform regulatory and transport functions, and gain energy. In contrast to M. jannaschii, A. fulgidus has fewer restriction-modification systems, and none of its genes appears to contain inteins. A quarter (651 ORFs) of the A. fulgidus genome encodes functionally uncharacterized yet conserved proteins, two-thirds of which are shared with M. jannaschii (428 ORFs). Another quarter of the genome encodes new proteins indicating substantial archaeal gene diversity.

Original languageEnglish (US)
Pages (from-to)364-370
Number of pages7
JournalNature
Volume390
Issue number6658
DOIs
StatePublished - Nov 27 1997

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Archaeoglobus fulgidus
Archaea
Sulfates
Methanocaldococcus
Genome
Open Reading Frames
Archaeal Genes
DNA Restriction-Modification Enzymes
Inteins
Biosynthetic Pathways
Automatic Data Processing
Sulfur
Information Systems
Base Pairing
Proteins
Nucleotides
Amino Acids
Genes

ASJC Scopus subject areas

  • General

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Klenk, H. P., Clayton, R. A., Tomb, J. F., White, O., Nelson, K. E., Ketchum, K. A., ... Craig Venter, J. (1997). The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus. Nature, 390(6658), 364-370. https://doi.org/10.1038/37052

The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus. / Klenk, Hans Peter; Clayton, Rebecca A.; Tomb, Jean Francois; White, Owen; Nelson, Karen E.; Ketchum, Karen A.; Dodson, Robert J.; Gwinn, Michelle; Hickey, Erin K.; Peterson, Jeremy D.; Richardson, Delwood L.; Kerlavage, Anthony R.; Graham, David E.; Krypides, Nikos C.; Fleischmann, Robert D.; Quackenbush, John; Lee, Norman H.; Sutton, Granger G.; Gill, Steven; Kirkness, Ewen F.; Dougherty, Brian A.; McKenney, Keith; Adams, Mark D.; Loftus, Brendan; Peterson, Scott; Reich, Claudia I.; McNeil, Leslie K.; Badger, Jonathan H.; Glodek, Anna; Zhou, Lixin; Overbeek, Ross; Gocayne, Jeannine D.; Wiedman, Janice F.; McDonald, Lisa; Utterback, Teresa; Cotton, Matthew D.; Spriggs, Tracy; Artiach, Patricia; Kaine, Brian P.; Sykes, Sean M.; Sadow, Paul W.; D'Andrea, Kurt P.; Bowman, Cheryl; Fujii, Claire; Garland, Stacey A.; Mason, Tanya M.; Olsen, Gary J.; Fraser, Claire M.; Smith, Hamilton O.; Woese, Carl R.; Craig Venter, J.

In: Nature, Vol. 390, No. 6658, 27.11.1997, p. 364-370.

Research output: Contribution to journalArticle

Klenk, HP, Clayton, RA, Tomb, JF, White, O, Nelson, KE, Ketchum, KA, Dodson, RJ, Gwinn, M, Hickey, EK, Peterson, JD, Richardson, DL, Kerlavage, AR, Graham, DE, Krypides, NC, Fleischmann, RD, Quackenbush, J, Lee, NH, Sutton, GG, Gill, S, Kirkness, EF, Dougherty, BA, McKenney, K, Adams, MD, Loftus, B, Peterson, S, Reich, CI, McNeil, LK, Badger, JH, Glodek, A, Zhou, L, Overbeek, R, Gocayne, JD, Wiedman, JF, McDonald, L, Utterback, T, Cotton, MD, Spriggs, T, Artiach, P, Kaine, BP, Sykes, SM, Sadow, PW, D'Andrea, KP, Bowman, C, Fujii, C, Garland, SA, Mason, TM, Olsen, GJ, Fraser, CM, Smith, HO, Woese, CR & Craig Venter, J 1997, 'The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus', Nature, vol. 390, no. 6658, pp. 364-370. https://doi.org/10.1038/37052
Klenk HP, Clayton RA, Tomb JF, White O, Nelson KE, Ketchum KA et al. The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus. Nature. 1997 Nov 27;390(6658):364-370. https://doi.org/10.1038/37052
Klenk, Hans Peter ; Clayton, Rebecca A. ; Tomb, Jean Francois ; White, Owen ; Nelson, Karen E. ; Ketchum, Karen A. ; Dodson, Robert J. ; Gwinn, Michelle ; Hickey, Erin K. ; Peterson, Jeremy D. ; Richardson, Delwood L. ; Kerlavage, Anthony R. ; Graham, David E. ; Krypides, Nikos C. ; Fleischmann, Robert D. ; Quackenbush, John ; Lee, Norman H. ; Sutton, Granger G. ; Gill, Steven ; Kirkness, Ewen F. ; Dougherty, Brian A. ; McKenney, Keith ; Adams, Mark D. ; Loftus, Brendan ; Peterson, Scott ; Reich, Claudia I. ; McNeil, Leslie K. ; Badger, Jonathan H. ; Glodek, Anna ; Zhou, Lixin ; Overbeek, Ross ; Gocayne, Jeannine D. ; Wiedman, Janice F. ; McDonald, Lisa ; Utterback, Teresa ; Cotton, Matthew D. ; Spriggs, Tracy ; Artiach, Patricia ; Kaine, Brian P. ; Sykes, Sean M. ; Sadow, Paul W. ; D'Andrea, Kurt P. ; Bowman, Cheryl ; Fujii, Claire ; Garland, Stacey A. ; Mason, Tanya M. ; Olsen, Gary J. ; Fraser, Claire M. ; Smith, Hamilton O. ; Woese, Carl R. ; Craig Venter, J. / The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus. In: Nature. 1997 ; Vol. 390, No. 6658. pp. 364-370.
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abstract = "Archaeoglobus fulgidus is the first sulphur-metabolizing organism to have its genome sequence determined. Its genome of 2,178,400 base pairs contains 2,436 open reading frames (ORFs). The information processing systems and the biosynthetic pathways for essential components (nucleotides, amino acids and cofactors) have extensive correlation with their counterparts in the archaeon Methanococcus jannaschii. The genomes of these two Archaea indicate dramatic differences in the way these organisms sense their environment, perform regulatory and transport functions, and gain energy. In contrast to M. jannaschii, A. fulgidus has fewer restriction-modification systems, and none of its genes appears to contain inteins. A quarter (651 ORFs) of the A. fulgidus genome encodes functionally uncharacterized yet conserved proteins, two-thirds of which are shared with M. jannaschii (428 ORFs). Another quarter of the genome encodes new proteins indicating substantial archaeal gene diversity.",
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AU - Ketchum, Karen A.

AU - Dodson, Robert J.

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AU - Lee, Norman H.

AU - Sutton, Granger G.

AU - Gill, Steven

AU - Kirkness, Ewen F.

AU - Dougherty, Brian A.

AU - McKenney, Keith

AU - Adams, Mark D.

AU - Loftus, Brendan

AU - Peterson, Scott

AU - Reich, Claudia I.

AU - McNeil, Leslie K.

AU - Badger, Jonathan H.

AU - Glodek, Anna

AU - Zhou, Lixin

AU - Overbeek, Ross

AU - Gocayne, Jeannine D.

AU - Wiedman, Janice F.

AU - McDonald, Lisa

AU - Utterback, Teresa

AU - Cotton, Matthew D.

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AU - Olsen, Gary J.

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AU - Smith, Hamilton O.

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