@article{33e8bda631874e24aa2d6ae4199c2bb8,
title = "The common marmoset as a translational model of age-related osteoarthritis",
abstract = "Age-related osteoarthritis (OA) is a degenerative joint disease characterized by pathological changes in nearly every intra- and peri-articular tissue that contributes to disability in older adults. Studying the etiology of age-related OA in humans is difficult due to an unpredictable onset and insidious nature. A barrier in developing OA modifying therapies is the lack of translational models that replicate human joint anatomy and age-related OA progression. The purpose of this study was to determine whether the common marmoset is a faithful model of human age-related knee OA. Semi-quantitative microCT scoring revealed greater radiographic OA in geriatric versus adult marmosets, and the age-related increase in OA prevalence was similar between marmosets and humans. Quantitative assessments indicate greater medial tibial cortical and trabecular bone thickness and heterogeneity in geriatric versus adult marmosets which is consistent with an age-related increase in focal subchondral bone sclerosis. Additionally, marmosets displayed an age-associated increase in synovitis and calcification of the meniscus and patella. Histological OA pathology in the medial tibial plateau was greater in geriatric versus adult marmosets driven by articular cartilage damage, proteoglycan loss, and altered chondrocyte cellularity. The age-associated increase in medial tibial cartilage OA pathology and meniscal calcification was greater in female versus male geriatric marmosets. Overall, marmosets largely replicate human OA as evident by similar 1) cartilage and skeletal morphology, 2) age-related progression in OA pathology, and 3) sex differences in OA pathology with increasing age. Collectively, these data suggest that the common marmoset is a highly translatable model of the naturally occurring, age-related OA seen in humans.",
keywords = "Bone, Cartilage, Knee, Meniscus, Naturally occurring osteoarthritis, Non-human primate, Patella",
author = "Minton, {Dennis M.} and Ailiani, {Aditya R.} and Focht, {Michael D.K.} and Kersh, {Mariana E.} and Marolf, {Angela J.} and Santangelo, {Kelly S.} and Salmon, {Adam B.} and Konopka, {Adam R.}",
note = "This work is supported by supported by NIH-NIA R21-AG067464 (to ARK), NIH-NIA R01-AG050797 (to ABS), the San Antonio Nathan Shock Center (P30-AG013319), and the San Antonio Claude D. Pepper Center (P30-AG044271). DMM is supported by NIH-NIA T32-AG000213. The Konopka Laboratory is also supported by NIH-NIA U01-AG076941, U01-AG081482, Impetus Longevity Grant by the Norn Group and Hevolution Foundation, and New Investigator Award from AFAR and Hevolution Foundation. \u03BCCT imaging was conducted at the Biomedical Imaging Center of the Beckman Institute for Advanced Science and Technology at the University of Illinois Urbana-Champaign. The Konopka Laboratory is also supported by startup and other funds from the University of Wisconsin-Madison School of Medicine and Public Health and Department of Medicine. This work was supported using facilities and resources from the William S. Middleton Memorial Veterans Hospital and utilized the facilities and services of the University of Wisconsin Translational Research Initiatives in Pathology (TRIP) laboratory, which is supported by the University of Wisconsin Department of Pathology and Laboratory Medicine and Carbone Cancer Center (P30 CA014520). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, the Department of Veterans Affairs, or the United States Government. This work is supported by supported by NIH-NIA R21-AG067464 (to ARK), NIH-NIA R01-AG050797 (to ABS), the San Antonio Nathan Shock Center (P30-AG013319), and the San Antonio Claude D. Pepper Center (P30-AG044271). DMM is supported by NIH-NIA T32-AG000213. The Konopka Laboratory is also supported by NIH-NIA U01-AG076941, U01-AG081482, Impetus Longevity Grant by the Norn Group and Hevolution Foundation, and New Investigator Award from AFAR and Hevolution Foundation. \u03BCCT imaging was conducted at the Biomedical Imaging Center of the Beckman Institute for Advanced Science and Technology at the University of Illinois Urbana-Champaign. The Konopka Laboratory is also supported by startup and other funds from the University of Wisconsin-Madison School of Medicine and Public Health and Department of Medicine. This work was supported using facilities and resources from the William S. Middleton Memorial Veterans Hospital and utilized the facilities and services of the University of Wisconsin Translational Research Initiatives in Pathology (TRIP) laboratory, which is supported by the University of Wisconsin\u00A0Department of Pathology and Laboratory Medicine and\u00A0Carbone Cancer Center (P30 CA014520).\u00A0The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, the Department of Veterans Affairs, or the United States Government.",
year = "2024",
month = jun,
doi = "10.1007/s11357-024-01103-5",
language = "English (US)",
volume = "46",
pages = "2827--2847",
journal = "GeroScience",
issn = "2509-2715",
publisher = "Springer",
number = "3",
}