The challenge of converting gram-positive-only compounds into broad-spectrum antibiotics

Keyphrases

• Escherichia Coli 100%
• Antibiotics 100%
• Gram-positive 100%
• Broad-spectrum Antibiotics 100%
• Small Molecules 50%
• Primary Amines 50%
• Three-dimensionality 50%
• Molecular Properties 50%
• Ionizable 50%
• Gram-negative Bacteria 50%
• Gram-negative 50%
• Historical Data 50%
• Drug Class 50%
• Bacterial Infection 50%
• New Antibiotics 50%
• Drug Shortage 50%
• Multidrug-resistant Gram-negative Bacteria 50%
• Globularity 50%
• Rotatable Bonds 50%

Biochemistry, Genetics and Molecular Biology

• Escherichia coli 100%
• Infectious Agent 50%
• Small Molecule 50%
• Gram Negative Bacterium 50%
• Retrospective Study 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Antibiotic Agent 100%
• Escherichia coli 40%
• Antiinfective Agent 20%
• Infectious Agent 20%
• Gram Negative Bacterium 20%
• Retrospective Study 20%
• Gram Negative Infection 20%