The cell biology of regeneration

Ryan S. King, Phillip A. Newmark

Research output: Contribution to journalReview articlepeer-review

Abstract

Regeneration of complex structures after injury requires dramatic changes in cellular behavior. Regenerating tissues initiate a program that includes diverse processes such as wound healing, cell death, dedifferentiation, and stem (or progenitor) cell proliferation; furthermore, newly regenerated tissues must integrate polarity and positional identity cues with preexisting body structures. Gene knockdown approaches and transgenesis-based lineage and functional analyses have been instrumental in deciphering various aspects of regenerative processes in diverse animal models for studying regeneration.

Original languageEnglish (US)
Pages (from-to)553-562
Number of pages10
JournalJournal of Cell Biology
Volume196
Issue number5
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • Cell Biology

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