The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis

Steven Lin, John E. Cronan

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The pimelate moiety of biotin is made by a modified fatty acid synthesis pathway. Results: The first reaction is O-methylation of the free carboxyl of malonyl-acyl carrier protein. Conclusion: The methyl acceptor is malonyl-acyl carrier protein and not malonyl-CoA. Significance: Demonstration of this enzymatic activity completes the E. coli biotin synthetic pathway.

Original languageEnglish (US)
Pages (from-to)37010-37020
Number of pages11
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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