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The Barrier Properties of Biological Membranes Dictate How Cells Experience Oxidative Stress

Research output: Contribution to journalArticlepeer-review

Abstract

Molecular oxygen, superoxide, and hydrogen peroxide are related oxidants that can each impair the growth of microorganisms. Strikingly, these species exhibit large differences in their abilities to cross biological membranes. This Perspective explains the basis of those differences, and it describes natural situations in which the permeability of membranes to oxidants determines the amount of stress that a bacterium experiences.

Original languageEnglish (US)
Pages (from-to)454-463
Number of pages10
JournalMolecular Microbiology
Volume123
Issue number5
Early online dateMar 17 2025
DOIs
StatePublished - May 2025

Keywords

  • hydrogen peroxide
  • obligate anaerobiosis
  • oxidative stress
  • superoxide

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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