The association between N-methylglucamine antimoniate and pancreatitis in dogs with leishmaniasis

A. Boari; M. Pierantozzi; G. Aste; S. Pantaleo; F. Di Silverio; G. Fanini; L. Lorentzen; David A Williams

doi:10.1007/978-3-642-23271-8_11

The association between N-methylglucamine antimoniate and pancreatitis in dogs with leishmaniasis

A. Boari, M. Pierantozzi, G. Aste, S. Pantaleo, F. Di Silverio, G. Fanini, L. Lorentzen, David A Williams

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

In this study, the possible association between pancreatitis and treatment with methylglucamine antimoniate (MA) in dogs with leishmaniasis was evaluated. Of the 20 dogs included, three dogs showed clinical signs of pancreatitis. Abdominal ultrasound abnormalities suggestive of pancreatitis were observed in two dogs, and increased cPLI was observed in four cases. The statistical results showed a low probability of development of pancreatitis in patients treated with MA. However, considering the possible recurrence of pancreatitis in four cases in our study, we suggest that dogs treated with MA should be evaluated for pancreatitis, especially when compatible clinical signs are present.

Original language	English (US)
Title of host publication	Veterinary Science
Subtitle of host publication	Current Aspects in Biology, Animal Pathology, Clinic and Food Hygiene
Publisher	Springer
Pages	65-69
Number of pages	5
Volume	9783642232718
ISBN (Electronic)	9783642232718
ISBN (Print)	3642232701, 9783642232701
DOIs	https://doi.org/10.1007/978-3-642-23271-8_11
State	Published - Mar 1 2012

Keywords

Dog
Leishmaniasis
Meglumine antimoniate
Pancreatitis

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)

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10.1007/978-3-642-23271-8_11

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Boari, A., Pierantozzi, M., Aste, G., Pantaleo, S., Di Silverio, F., Fanini, G., Lorentzen, L., & Williams, D. A. (2012). The association between N-methylglucamine antimoniate and pancreatitis in dogs with leishmaniasis. In Veterinary Science: Current Aspects in Biology, Animal Pathology, Clinic and Food Hygiene (Vol. 9783642232718, pp. 65-69). Springer. https://doi.org/10.1007/978-3-642-23271-8_11

Boari, A, Pierantozzi, M, Aste, G, Pantaleo, S, Di Silverio, F, Fanini, G, Lorentzen, L & Williams, DA 2012, The association between N-methylglucamine antimoniate and pancreatitis in dogs with leishmaniasis. in Veterinary Science: Current Aspects in Biology, Animal Pathology, Clinic and Food Hygiene. vol. 9783642232718, Springer, pp. 65-69. https://doi.org/10.1007/978-3-642-23271-8_11

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abstract = "In this study, the possible association between pancreatitis and treatment with methylglucamine antimoniate (MA) in dogs with leishmaniasis was evaluated. Of the 20 dogs included, three dogs showed clinical signs of pancreatitis. Abdominal ultrasound abnormalities suggestive of pancreatitis were observed in two dogs, and increased cPLI was observed in four cases. The statistical results showed a low probability of development of pancreatitis in patients treated with MA. However, considering the possible recurrence of pancreatitis in four cases in our study, we suggest that dogs treated with MA should be evaluated for pancreatitis, especially when compatible clinical signs are present.",

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AU - Boari, A.

AU - Pierantozzi, M.

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AU - Pantaleo, S.

AU - Di Silverio, F.

AU - Fanini, G.

AU - Lorentzen, L.

AU - Williams, David A

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AB - In this study, the possible association between pancreatitis and treatment with methylglucamine antimoniate (MA) in dogs with leishmaniasis was evaluated. Of the 20 dogs included, three dogs showed clinical signs of pancreatitis. Abdominal ultrasound abnormalities suggestive of pancreatitis were observed in two dogs, and increased cPLI was observed in four cases. The statistical results showed a low probability of development of pancreatitis in patients treated with MA. However, considering the possible recurrence of pancreatitis in four cases in our study, we suggest that dogs treated with MA should be evaluated for pancreatitis, especially when compatible clinical signs are present.

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KW - Leishmaniasis

KW - Meglumine antimoniate

KW - Pancreatitis

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The association between N-methylglucamine antimoniate and pancreatitis in dogs with leishmaniasis

Abstract

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