TY - JOUR
T1 - The Alpha-SPECT-Mini
T2 - A Small-Animal SPECT System Based on Hyperspectral Compound-Eye Gamma Cameras
AU - Zannoni, Elena Maria
AU - Yang, Can
AU - Cai, Ling
AU - Wilson, Matthew D.
AU - Chen, Chin Tu
AU - Meng, Ling Jian
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2025
Y1 - 2025
N2 - There is a rising interest in Single Photon Emission Computed Tomography (SPECT) imaging systems with improved energy resolution to facilitate multi-functional molecular imaging applications, such as alpha-emitter radiopharmaceutical therapy (αQ-RPT). In this paper, we report the design and evaluation of the Alpha-SPECT-Mini system that offers an ultrahigh energy resolution and high sensitivity for small animal studies. The Alpha-SPECT-Mini system is constructed based on small-pixel CdTe detectors that offers sub-1keV Full-Width-Half-Maximum (FWHM) energy resolution for single pixel events and an average 2.5keV energy resolution at 122 keV and 3.5 keV at 218 keV over 153600 pixels in the system. This allows to easily identify X-and gamma-ray contributions in densely populated spectra, such as from the Ac-225 decay chain. The system uses a 96-loft-hole collimator and six stationary detection panels in a full ring geometry. Finally, the system performance is demonstrated using Tc-99m-and Ac-225-filled resolution and image quality (IQ) phantoms. We have experimentally demonstrated that the Alpha-SPECT-Mini is a highperformance imaging system capable of imaging alpha-emitters in preclinical applications.
AB - There is a rising interest in Single Photon Emission Computed Tomography (SPECT) imaging systems with improved energy resolution to facilitate multi-functional molecular imaging applications, such as alpha-emitter radiopharmaceutical therapy (αQ-RPT). In this paper, we report the design and evaluation of the Alpha-SPECT-Mini system that offers an ultrahigh energy resolution and high sensitivity for small animal studies. The Alpha-SPECT-Mini system is constructed based on small-pixel CdTe detectors that offers sub-1keV Full-Width-Half-Maximum (FWHM) energy resolution for single pixel events and an average 2.5keV energy resolution at 122 keV and 3.5 keV at 218 keV over 153600 pixels in the system. This allows to easily identify X-and gamma-ray contributions in densely populated spectra, such as from the Ac-225 decay chain. The system uses a 96-loft-hole collimator and six stationary detection panels in a full ring geometry. Finally, the system performance is demonstrated using Tc-99m-and Ac-225-filled resolution and image quality (IQ) phantoms. We have experimentally demonstrated that the Alpha-SPECT-Mini is a highperformance imaging system capable of imaging alpha-emitters in preclinical applications.
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U2 - 10.1109/TRPMS.2025.3560558
DO - 10.1109/TRPMS.2025.3560558
M3 - Article
AN - SCOPUS:105002811979
SN - 2469-7311
JO - IEEE Transactions on Radiation and Plasma Medical Sciences
JF - IEEE Transactions on Radiation and Plasma Medical Sciences
ER -