TY - JOUR
T1 - The α-A-crystallin and cystathionine β-synthase genes are physically very closely linked in proximal mouse chromosome 17
AU - Stubbs, Lisa
AU - Kraus, Jan
AU - Lehrach, Hans
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1990/6
Y1 - 1990/6
N2 - Murine genes homologous to those contributing to the Down syndrome (DS) phenotype in man are currently of interest because of their potential for providing animal models for the study of specific DS symptoms. Most of the genes mapping to human chromosome 21q22, where the DS genes are concentrated, are related to sequences located on mouse chromosome 16. Others, however, are known to map to mouse chromosome 10, and two genes, cystathionine β-synthase (Cbs) and α-A-crystallin (Crya-1), have been localized to the proximal portion of mouse chromosome 17. In this paper, we show that the two genes mapping to human chromosome 21q22 and mouse chromosome 17 are very tightly linked in mouse, being separated by at least 70 kb, but not more than 130 kb. The very close physical linkage of mouse Cbs and Crya-1, combined with data that localize homologs of the closely flanking markers H2k and Pim-1 to human chromosome 6, suggests that the human 21q22/mouse chromosome 17 conserved segment is of a very limited total physical size and is likely to contain a relatively small number of genes.
AB - Murine genes homologous to those contributing to the Down syndrome (DS) phenotype in man are currently of interest because of their potential for providing animal models for the study of specific DS symptoms. Most of the genes mapping to human chromosome 21q22, where the DS genes are concentrated, are related to sequences located on mouse chromosome 16. Others, however, are known to map to mouse chromosome 10, and two genes, cystathionine β-synthase (Cbs) and α-A-crystallin (Crya-1), have been localized to the proximal portion of mouse chromosome 17. In this paper, we show that the two genes mapping to human chromosome 21q22 and mouse chromosome 17 are very tightly linked in mouse, being separated by at least 70 kb, but not more than 130 kb. The very close physical linkage of mouse Cbs and Crya-1, combined with data that localize homologs of the closely flanking markers H2k and Pim-1 to human chromosome 6, suggests that the human 21q22/mouse chromosome 17 conserved segment is of a very limited total physical size and is likely to contain a relatively small number of genes.
UR - http://www.scopus.com/inward/record.url?scp=0025364356&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025364356&partnerID=8YFLogxK
U2 - 10.1016/0888-7543(90)90553-7
DO - 10.1016/0888-7543(90)90553-7
M3 - Article
C2 - 2347594
AN - SCOPUS:0025364356
SN - 0888-7543
VL - 7
SP - 284
EP - 288
JO - Genomics
JF - Genomics
IS - 2
ER -