Tethered indoles as functionalizable ligands for the estrogen receptor

Bridget G. Trogden, Sung Hoon Kim, Shuyi Lee, John A. Katzenellenbogen

Research output: Contribution to journalArticlepeer-review


To create ligands for the estrogen receptor that contain pendant groups for tethering to a poly(amido)amine (PAMAM) dendrimer, we have explored a class of N-substituted 2-phenyl indoles. Attachment of tethers of different length and chemical nature to this non-steroidal indole scaffold gave high affinity ligand-tether conjugates that can be easily functionalized. To further explore the utility of this system, an indole-conjugated dendrimer was prepared and evaluated as an estrogen receptor ligand.

Original languageEnglish (US)
Pages (from-to)485-488
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number2
StatePublished - Jan 15 2009


  • Estrogen receptor
  • Indole
  • PAMAM dendrimer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


Dive into the research topics of 'Tethered indoles as functionalizable ligands for the estrogen receptor'. Together they form a unique fingerprint.

Cite this