@article{8cf05d68c3874240bf497e03ab8ea989,
title = "Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project",
abstract = "Companion dogs are a powerful model for aging research given their morphologic and genetic variability, risk for age-related disease, and habitation of the human environment. In addition, the shorter life expectancy of dogs compared to human beings provides a unique opportunity for an accelerated timeline to test interventions that might extend healthy lifespan. The Test of Rapamycin In Aging Dogs (TRIAD) randomized clinical trial is a parallel-group, double-masked, randomized, placebo-controlled, multicenter trial that will test the ability of rapamycin to prolong lifespan and improve several healthspan metrics in healthy, middle-aged dogs recruited from Dog Aging Project participants. Here, we describe the rationale, design, and goals of the TRIAD randomized clinical trial, the first rigorous test of a pharmacologic intervention against biological aging with lifespan and healthspan metrics as endpoints to be performed outside of the laboratory in any species.",
keywords = "Canine, Healthspan, Life span, Lifespan, Longevity, Rapamycin",
author = "{the Dog Aging Project Consortium} and Coleman, {Amanda E.} and Creevy, {Kate E.} and Rozalyn Anderson and Reed, {May J.} and Fajt, {Virginia R.} and Aicher, {Kathleen M.} and Genna Atiee and Barnett, {Brian G.} and Baumwart, {Ryan D.} and Beth Boudreau and Cunningham, {Suzanne M.} and Dunbar, {Matthew D.} and Bobbie Ditzler and Ferguson, {Anna M.} and Forsyth, {Kiersten K.} and Gambino, {Anya N.} and Gordon, {Sonya G.} and Hammond, {Hillary K.} and Holland, {Sydney N.} and Iannaccone, {Mary K.} and Kate Illing and Saki Kadotani and Knowles, {Shelby A.} and MacLean, {Evan L.} and Maran, {Brian A.} and Markovic, {Lauren E.} and Stephanie McGrath and Melvin, {Rachel L.} and Mueller, {Mikaela S.} and Nelson, {O. Lynne} and Olby, {Natasha J.} and Pancotto, {Theresa E.} and Elizabeth Parsley and Potter, {Brianna M.} and Prescott, {Jena O.} and Saunders, {Ashley B.} and Sawyer, {Holly M.} and Scansen, {Brian A.} and Schmid, {Sarah M.} and Smith, {Courtney C.} and Tjostheim, {Sonja S.} and Tolbert, {M. Katherine} and Tropf, {Melissa A.} and Visser, {Lance C.} and Ward, {Jessica L.} and Wesselowski, {Sonya R.} and Windsor, {Rebecca C.} and Yang, {Vicky K.} and Audrey Ruple and Promislow, {Daniel E.L.}",
note = "The Dog Aging Project is supported by grant UI9AG057377 (AEC, KEC, VF, GA, BGB, BB, BD, AF, KKF, ANG, SNH, MI, KI, SAK, RLM, JOP, SMS, AR, DELP, MK,) from the National Institute on Aging, a part of the National Institutes of Health, and by private donations.",
year = "2025",
month = feb,
day = "14",
doi = "10.1007/s11357-024-01484-7",
language = "English (US)",
journal = "GeroScience",
issn = "2509-2715",
publisher = "Springer",
}