Temporal variation selects for diet-microbe co-metabolic traits in the gut of Gorilla spp

Andres Gomez, Jessica M. Rothman, Klara Petrzelkova, Carl J. Yeoman, Klara Vlckova, Juan D. Umaña, Monica Carr, David Modry, Angelique Todd, Manolito Torralba, Karen E. Nelson, Rebecca M. Stumpf, Brenda A. Wilson, Ran Blekhman, Bryan A. White, Steven R. Leigh

Research output: Contribution to journalArticle

Abstract

Although the critical role that our gastrointestinal microbes play in host physiology is now well established, we know little about the factors that influenced the evolution of primate gut microbiomes. To further understand current gut microbiome configurations and diet-microbe co-metabolic fingerprints in primates, from an evolutionary perspective, we characterized fecal bacterial communities and metabolomic profiles in 228 fecal samples of lowland and mountain gorillas (G. g. gorilla and G. b. beringei, respectively), our closest evolutionary relatives after chimpanzees. Our results demonstrate that the gut microbiomes and metabolomes of these two species exhibit significantly different patterns. This is supported by increased abundance of metabolites and bacterial taxa associated with fiber metabolism in mountain gorillas, and enrichment of markers associated with simple sugar, lipid and sterol turnover in the lowland species. However, longitudinal sampling shows that both species' microbiomes and metabolomes converge when hosts face similar dietary constraints, associated with low fruit availability in their habitats. By showing differences and convergence of diet-microbe co-metabolic fingerprints in two geographically isolated primate species, under specific dietary stimuli, we suggest that dietary constraints triggered during their adaptive radiation were potential factors behind the species-specific microbiome patterns observed in primates today.

Original languageEnglish (US)
Pages (from-to)514-526
Number of pages13
JournalISME Journal
Volume10
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Gorilla gorilla
Gorilla
Primates
temporal variation
digestive system
primate
diet
Diet
microorganisms
Metabolome
Microbiota
Dermatoglyphics
metabolome
lowlands
Metabolomics
Pan troglodytes
mountains
Sterols
adaptive radiation
mountain

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Gomez, A., Rothman, J. M., Petrzelkova, K., Yeoman, C. J., Vlckova, K., Umaña, J. D., ... Leigh, S. R. (2016). Temporal variation selects for diet-microbe co-metabolic traits in the gut of Gorilla spp. ISME Journal, 10(2), 514-526. https://doi.org/10.1038/ismej.2015.146

Temporal variation selects for diet-microbe co-metabolic traits in the gut of Gorilla spp. / Gomez, Andres; Rothman, Jessica M.; Petrzelkova, Klara; Yeoman, Carl J.; Vlckova, Klara; Umaña, Juan D.; Carr, Monica; Modry, David; Todd, Angelique; Torralba, Manolito; Nelson, Karen E.; Stumpf, Rebecca M.; Wilson, Brenda A.; Blekhman, Ran; White, Bryan A.; Leigh, Steven R.

In: ISME Journal, Vol. 10, No. 2, 01.02.2016, p. 514-526.

Research output: Contribution to journalArticle

Gomez, A, Rothman, JM, Petrzelkova, K, Yeoman, CJ, Vlckova, K, Umaña, JD, Carr, M, Modry, D, Todd, A, Torralba, M, Nelson, KE, Stumpf, RM, Wilson, BA, Blekhman, R, White, BA & Leigh, SR 2016, 'Temporal variation selects for diet-microbe co-metabolic traits in the gut of Gorilla spp', ISME Journal, vol. 10, no. 2, pp. 514-526. https://doi.org/10.1038/ismej.2015.146
Gomez A, Rothman JM, Petrzelkova K, Yeoman CJ, Vlckova K, Umaña JD et al. Temporal variation selects for diet-microbe co-metabolic traits in the gut of Gorilla spp. ISME Journal. 2016 Feb 1;10(2):514-526. https://doi.org/10.1038/ismej.2015.146
Gomez, Andres ; Rothman, Jessica M. ; Petrzelkova, Klara ; Yeoman, Carl J. ; Vlckova, Klara ; Umaña, Juan D. ; Carr, Monica ; Modry, David ; Todd, Angelique ; Torralba, Manolito ; Nelson, Karen E. ; Stumpf, Rebecca M. ; Wilson, Brenda A. ; Blekhman, Ran ; White, Bryan A. ; Leigh, Steven R. / Temporal variation selects for diet-microbe co-metabolic traits in the gut of Gorilla spp. In: ISME Journal. 2016 ; Vol. 10, No. 2. pp. 514-526.
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