Temperature effect on bilirubin adsorption with the anion exchange resin BR-601

D. H. Tang, P. S. Malchesky, S. Omokawa, M. Matsushita, C. R. Davies, Y. Nose

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma perfusion with the anion exchange resin BR-601 is an effective method to treat patients with hepatic failure and hyperbilirubinemia. To assess the temperature dependency of bilirubin sorption in vitro, isotherm studies with human pathologic plasmas and an albumin-bilirubin solution were carried out. Results showed that BR-601 was more effective at 37°C and 42°C than at 4°C and 25°C for sorbing bilirubin. Therefore, plasma sorption at near physiologic temperature would be expected to be more efficient for plasma treatment than sorption at ambient temperature.

Original languageEnglish (US)
Pages (from-to)659-663
Number of pages5
JournalInternational Journal of Artificial Organs
Volume12
Issue number10
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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