Temperature and perfusion responses of muscle and lung tissue during chronic heating in vivo

G. M. Saidel, C. R. Davies, E. H. Liu, H. Harasaki

Research output: Contribution to journalArticle

Abstract

For the first time, both temperature and perfusion responses have been obtained from in vivo studies of chronically heated lung and muscle tissue of calves. In each tissue, the spatial temperature distribution was measured by thermistors placed in needles at several distances from an implanted heated disc. A perfusion parameter was defined for a bioheat transfer model that describes temperature dynamics with distance from the heated disc. Estimates of perfusion were obtained by a least-squares fit of the model output to a step change in heat flux. Except for short transient experiments several times a week, a constant heat flux of 0.04, 0.06 or 0.08 W cm-2 was maintained at the disc surface for up to seven weeks. At the higher heat fluxes, the steady-state tissue temperature decreased with heating duration. Also, the characteristic time constants of the tissues decreased with heating duration. Muscle perfusion showed a statistically significant increase during chronic heating. Tissue adapts to chronic heating above 42°C by allowing more capillary blood flow that increases heat loss to reduce tissue temperature.

Original languageEnglish (US)
Pages (from-to)126-133
Number of pages8
JournalMedical and Biological Engineering and Computing
Volume39
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Chronic heat adaptation
  • Heat-induced angiogenesis
  • Perfusion
  • Temperature dynamics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Computer Science Applications

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