@article{d9deac448e8b48a9be91073c8267949b,
title = "Targeting systemic and gut microbial metabolism in ER+ breast cancer",
abstract = "Estrogen receptor-positive (ER+) breast tumors have a better overall prognosis than ER− tumors; however, there is a sustained risk of recurrence. Mounting evidence indicates that genetic and epigenetic changes associated with resistance impact critical signaling pathways governing cell metabolism. This review delves into recent literature concerning the metabolic pathways regulated in ER+ breast tumors by the availability of nutrients and endocrine therapies and summarizes research on how changes in systemic and gut microbial metabolism can affect ER activity and responsiveness to endocrine therapy. As targeting of metabolic pathways using dietary or pharmacological approaches enters the clinic, we provide an overview of the supporting literature and suggest future directions.",
keywords = "breast cancer, diet, estrogen receptor, metabolism, microbiome, therapy resistance",
author = "Hannah Heath and Mogol, \{Ayca Nazli\} and \{Santaliz Casiano\}, Ashlie and Qianying Zuo and Zeynep Madak-Erdogan",
note = "Research reported in this review was supported by the Cancer Scholars for Translational and Applied Research (CSTAR) Program sponsored by the Cancer Center at Illinois and the Carle Cancer Center under Award Number CST EP082021 (to A.N.M.). Research reported in this review was supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Award Number T32EB019944 (to A.S.C.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Research reported in this review was supported by the Graduate College Fellowship (H.H.). The authors have nothing to disclose. Research reported in this review was supported by the Cancer Scholars for Translational and Applied Research (CSTAR) Program sponsored by the Cancer Center at Illinois and the Carle Cancer Center under Award Number CST EP082021 (to A.N.M.). Research reported in this review was supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Award Number T32EB019944 (to A.S.C.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Research reported in this review was supported by the Graduate College Fellowship (H.H.).",
year = "2024",
month = apr,
doi = "10.1016/j.tem.2023.12.008",
language = "English (US)",
volume = "35",
pages = "321--330",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Inc.",
number = "4",
}