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Targeting isoprenoid biosynthesis for drug discovery: Bench to bedside
Eric Oldfield
Chemistry
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peer-review
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Keyphrases
Drug Discovery
100%
Isoprenoid Synthesis
100%
Bench to Bedside
100%
CrtM
75%
Tumor Cells
50%
Carotenoids
50%
Metallacycles
50%
Alkenes
50%
Isoprenoids
50%
Diphosphate
50%
Inhibition Studies
50%
Bone Resorption
50%
Drug Lead
50%
Dimethylallyl Diphosphate (DMAPP)
50%
IspH
50%
Staphyloxanthin
50%
Antiparasitic Agents
50%
Isopentenyl Diphosphate
50%
FPP®
50%
Small Molecules
25%
Structure Function
25%
Propylene
25%
Macromolecules
25%
Large Classes
25%
Condensation
25%
Methyl
25%
Alkynes
25%
Mechanistic Studies
25%
Effective Compounds
25%
T Cells
25%
Reactive Oxygen Species
25%
Neutrophils
25%
Oncology
25%
Drug Resistance
25%
Innate Immune Response
25%
Allylic Alcohols
25%
Anticancer Drugs
25%
Invasiveness
25%
New Leads
25%
Pathogenic Bacteria
25%
Heart Disease
25%
Organometallic Chemistry
25%
Terpenoids
25%
Organometallic Species
25%
New Drugs
25%
Protozoa
25%
Virulence Factors
25%
Isoprenoid Pathway
25%
Malaria Parasite
25%
Anti-infective
25%
Osteoporosis
25%
Staphylococcus Aureus
25%
New Therapeutic Approaches
25%
Malaria Infection
25%
Antifungal Activity
25%
Knowledge-based Approach
25%
Bisphosphonates
25%
Trypanosoma Cruzi (T. cruzi)
25%
Sesquiterpenes
25%
Low Cholesterol
25%
Sterol Biosynthesis
25%
Carbocations
25%
HMBPP
25%
Lipophilic Bisphosphonate
25%
Dehydrosqualene Synthase
25%
Squalene Synthase Inhibitors
25%
Squalene Synthase
25%
Terpene Synthase
25%
Farnesyl Pyrophosphate
25%
Protein Prenylation
25%
FPP Synthase
25%
Amiodarone
25%
Ergosterol Biosynthesis
25%
Neglected Tropical Diseases
25%
Oxidosqualene Cyclase
25%
Fosamax
25%
Cholesterol-lowering Agents
25%
Cholesterol-lowering Drugs
25%
Drug Block
25%
Tuberculosis Infection
25%
Staph Infection
25%
Lipitor
25%
Case Knowledge
25%
Heart Drugs
25%
Chemistry
Drug Discovery
100%
Isoprenoid
100%
Bench-to-Bedside
100%
Carotenoid
28%
Alkene
28%
Metallacycle
28%
% Inhibition
28%
Isopentenyl Diphosphate
28%
Antiparasitic Agent
28%
Staphyloxanthin
28%
Anticholesteremic Agent
28%
Chemistry
14%
Structure
14%
Metallocene
14%
Cyclopropane
14%
Condensation
14%
Macromolecule
14%
Alkyne
14%
Mechanistic Study
14%
Allyl Alcohol
14%
Antineoplastic Agent
14%
Reactive Oxygen Species
14%
Organometallic Chemistry
14%
Terpenoid
14%
Antiinfective
14%
Carbocation
14%
Antifungal
14%
Presqualene Diphosphate
14%
Sterol
14%
Farnesyl Diphosphate
14%
Sesquiterpene
14%
Diphosphate(4-)
14%
Virulence Factor
14%
Amiodarone
14%
Ergosterol
14%
Triterpene
14%
Squalene
14%
EC 2.5.1.21 (Squalene Synthase) Inhibitor
14%
Prenylation
14%
Pharmacology, Toxicology and Pharmaceutical Science
Isoprenoid
100%
Drug Discovery
100%
Pyrophosphate
57%
Synthetase
42%
Neoplasm
28%
Alkene
28%
Carotenoid
28%
Bisphosphonic Acid Derivative
28%
Antiparasitic Agent
28%
Isopentenyl Diphosphate
28%
Hypocholesterolemic Agent
28%
Infection
14%
Cyclopropane
14%
Alkyne
14%
Allyl Alcohol
14%
Atorvastatin
14%
Anticarcinogen
14%
Reactive Oxygen Metabolite
14%
Drug Resistance
14%
Virulence Factor
14%
Staphylococcus Aureus
14%
Sterol
14%
Heart Disease
14%
Plasmodium
14%
Antifungal Activity
14%
Sesquiterpene
14%
Protozoon
14%
Carbocation
14%
Trypanosoma Cruzi
14%
Farnesyl Diphosphate
14%
Alendronic Acid
14%
Squalene Synthase
14%
Ergosterol
14%
Amiodarone
14%
Tropical Disease
14%
Triterpene
14%
Terpenoid
14%
Squalene Synthase Inhibitor
14%
Biochemistry, Genetics and Molecular Biology
Isoprenoids Biosynthesis
100%
Pyrophosphate
100%
Synthase
71%
Anabolism
42%
Enzyme
28%
Carotenoid
28%
Osteolysis
28%
T Cell
14%
Small Molecule
14%
Macromolecule
14%
Drug Resistance
14%
Innate Immunity
14%
Neutrophil Granulocyte
14%
Protozoon
14%
Ergosterol
14%
Anticancer
14%
Iron-Sulfur Protein
14%
Virulence Factor
14%
Plasmodium
14%
Sterol Synthesis
14%
Cyclopropane
14%
Staphylococcus Aureus
14%
Antifungal Activity
14%
Cyclase
14%
Trypanosoma Cruzi
14%
Protein Prenylation
14%
Amiodarone
14%