Targeted photothermal lysis of the pathogenic bacteria, pseudomonas aeruginosa, with gold nanorods

R. Sean Norman, John W. Stone, Anand Gole, Catherine J. Murphy, Tara L. Sabo-Attwood

Research output: Contribution to journalArticle

Abstract

Increases in the prevalence of antibiotic resistant bacteria require new approaches for the treatment of infectious bacterial pathogens. It is now clear that a nanotechnology-driven approach using nanoparticles to selectively target and destroy pathogenic bacteria can be successfully implemented. We have explored this approach by using gold nanorods that have been covalently linked to primary antibodies to selectively destroy the pathogenic Gram-negative bacterium, Pseudomonas aeruginosa. We find that, following nanorod attachment to the bacterial cell surface, exposure to near-infrared radiation results in a significant reduction in bacterial cell viability.

Original languageEnglish (US)
Pages (from-to)302-306
Number of pages5
JournalNano letters
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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