Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy

Xiang Hong Peng, Ximei Qian, Hui Mao, Andrew Y. Wang, Zhuo G. Chen, Shuming Nie, Dong M. Shin

Research output: Contribution to journalReview article

Abstract

Magnetic iron oxide (IO) nanoparticles with a long blood retention time, biodegradability and low toxicity have emerged as one of the primary nanomaterials for biomedical applications in vitro and in vivo. IO nanoparticles have a large surface area and can be engineered to provide a large number of functional groups for cross-linking to tumor-targeting ligands such as monoclonal antibodies, peptides, or small molecules for diagnostic imaging or delivery of therapeutic agents. IO nanoparticles possess unique paramagnetic properties, which generate significant susceptibility effects resulting in strong T2 and T*2 contrast, as well as T1 effects at very low concentrations for magnetic resonance imaging (MRI), which is widely used for clinical oncology imaging. We review recent advances in the development of targeted IO nanoparticles for tumor imaging and therapy.

Original languageEnglish (US)
Pages (from-to)311-321
Number of pages11
JournalInternational journal of nanomedicine
Volume3
Issue number3
StatePublished - 2008

Keywords

  • Iron oxide nanoparticles
  • MRI
  • Therapy
  • Tumor imaging

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Peng, X. H., Qian, X., Mao, H., Wang, A. Y., Chen, Z. G., Nie, S., & Shin, D. M. (2008). Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy. International journal of nanomedicine, 3(3), 311-321.