Target-site mutations conferring herbicide resistance

Brent P. Murphy, Patrick J. Tranel

Research output: Contribution to journalArticle


Mutations conferring evolved herbicide resistance in weeds are known in nine different herbicide sites of action. This review summarizes recently reported resistance-conferring mutations for each of these nine target sites. One emerging trend is an increase in reports of multiple mutations, including multiple amino acid changes at the glyphosate target site, as well as mutations involving two nucleotide changes at a single amino acid codon. Standard reference sequences are suggested for target sites for which standards do not already exist. We also discuss experimental approaches for investigating cross-resistance patterns and for investigating fitness costs of specific target-site mutations.

Original languageEnglish (US)
Article number382
Issue number10
StatePublished - Oct 2019


  • ACCase
  • Acetolactate synthase
  • Auxin
  • D1 protein
  • Glutamine synthetase
  • PPO
  • Phytoene desaturase
  • Tubulin

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Plant Science

Fingerprint Dive into the research topics of 'Target-site mutations conferring herbicide resistance'. Together they form a unique fingerprint.

  • Cite this