Tandem reactions combining biocatalysts and chemical catalysts for asymmetric synthesis

Yajie Wang, Huimin Zhao

Research output: Contribution to journalReview articlepeer-review


The application of biocatalysts in the synthesis of fine chemicals and medicinal compounds has grown significantly in recent years. Particularly, there is a growing interest in the development of one-pot tandem catalytic systems combining the reactivity of a chemical catalyst with the selectivity engendered by the active site of an enzyme. Such tandem catalytic systems can achieve levels of chemo-, regio-, and stereo-selectivities that are unattainable with a small molecule catalyst. In addition, artificial metalloenzymes widen the range of reactivities and catalyzed reactions that are potentially employable. This review highlights some of the recent examples in the past three years that combined transition metal catalysis with enzymatic catalysis. This field is still in its infancy. However, with recent advances in protein engineering, catalyst synthesis, artificial metalloenzymes and supramolecular assembly, there is great potential to develop more sophisticated tandem chemoenzymatic processes for the synthesis of structurally complex chemicals.

Original languageEnglish (US)
Article number194
Issue number12
StatePublished - Dec 1 2016


  • Artificial metalloenzyme
  • Asymmetric synthesis
  • Biocatalysis
  • Chemoenzymatic
  • Dynamic kinetic resolution
  • Tandem catalysis

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry


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