Tandem Inter [4 + 2]/Intra [3 + 2] Cycloadditions. 3. The Stereochemical Influence of the Lewis Acid

Scott E. Denmark, Mark E. Schnute

Research output: Contribution to journalArticle


trans-2-Phenylcyclohexanol has been employed as a chiral auxiliary in the inter [4 + 2]/intra [3 + 2] tandem cycloaddition of nitroalkenes with chiral vinyl ethers. A novel reversal of selectivity between cycloadditions catalyzed by the Lewis acids Ti(O-i-Pr)2Cl2 and MAPh has been discovered.

Original languageEnglish (US)
Pages (from-to)6738-6739
Number of pages2
JournalJournal of Organic Chemistry
Issue number24
StatePublished - Nov 1 1991


ASJC Scopus subject areas

  • Organic Chemistry

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