Tandem Imine Formation and Alkyne Metathesis Enabled by Catalyst Choice

Andrew J. Greenlee, Heyu Chen, Chloe I. Wendell, Jeffrey S. Moore

Research output: Contribution to journalArticlepeer-review


Three-rung molecular ladder 8 was prepared in one pot via tandem imine condensation and alkyne metathesis. Catalyst VI is demonstrated to successfully engender the metathesis of imine-bearing substrate 7, while catalyst III does not. The susceptibility of catalyst VI to deactivation by hydrolysis and ligand exchange is demonstrated. Assembly and disassembly of ladder 8 in one pot were demonstrated in the presence and absence of a Lewis acid catalyst.

Original languageEnglish (US)
Pages (from-to)8429-8436
Number of pages8
JournalJournal of Organic Chemistry
Issue number13
StatePublished - Jul 1 2022

ASJC Scopus subject areas

  • Organic Chemistry


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