Taking the pulse of aging: Mapping pulse pressure and elasticity in cerebral arteries with optical methods

Monica Fabiani, Kathy A. Low, Chin Hong Tan, Benjamin Zimmerman, Mark A. Fletcher, Nils Schneider-Garces, Edward L. Maclin, Antonio M. Chiarelli, Bradley P. Sutton, Gabriele Gratton

Research output: Contribution to journalArticle

Abstract

Cerebrovascular support is crucial for healthy cognitive and brain aging. Arterial stiffening is a cause of reduced brain blood flow, a predictor of cognitive decline, and a risk factor for cerebrovascular accidents and Alzheimer's disease. Arterial health is influenced by lifestyle factors, such as cardiorespiratory fitness (CRF). We investigated new noninvasive optical measures of cerebrovascular health, which provide estimates of arterial pulse parameters (pulse pressure, transit time, and compliance/elasticity) within specific cerebral arteries and cortical regions, and low-resolution maps of large superficial cerebral arteries. We studied naturally occurring variability in these parameters in adults (aged 55-87), and found that these indices of cerebrovascular health are negatively correlated with age and positively with CRF and gray and white matter volumes. Further, regional pulse transit time predicts specific neuropsychological performance.

Original languageEnglish (US)
Pages (from-to)1072-1088
Number of pages17
JournalPsychophysiology
Volume51
Issue number11
DOIs
StatePublished - Nov 1 2014

Keywords

  • Aging
  • Arterial compliance
  • Brain anatomy
  • Cardiorespiratory fitness (CRF)
  • Cerebrovascular health
  • Noninvasive optical imaging

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    Fabiani, M., Low, K. A., Tan, C. H., Zimmerman, B., Fletcher, M. A., Schneider-Garces, N., Maclin, E. L., Chiarelli, A. M., Sutton, B. P., & Gratton, G. (2014). Taking the pulse of aging: Mapping pulse pressure and elasticity in cerebral arteries with optical methods. Psychophysiology, 51(11), 1072-1088. https://doi.org/10.1111/psyp.12288