T-cell receptor binding affinities and kinetics

impact on T-cell activity and specificity

Jennifer D. Stone, Adam S. Chervin, David M Kranz

Research output: Contribution to journalReview article

Abstract

The interaction between the T-cell receptor (TCR) and its peptide-major histocompatibility complex (pepMHC) ligand plays a critical role in determining the activity and specificity of the T cell. The binding properties associated with these interactions have now been studied in many systems, providing a framework for a mechanistic understanding of the initial events that govern T-cell function. There have been various other reviews that have described the structural and biochemical features of TCR : pepMHC interactions. Here we provide an overview of four areas that directly impact our understanding of T-cell function, as viewed from the perspective of the TCR : pepMHC interaction: (1) relationships between T-cell activity and TCR : pepMHC binding parameters, (2) TCR affinity, avidity and clustering, (3) influence of coreceptors on pepMHC binding by TCRs and T-cell activity, and (4) impact of TCR binding affinity on antigenic peptide specificity.

Original languageEnglish (US)
Pages (from-to)165-176
Number of pages12
JournalImmunology
Volume126
Issue number2
DOIs
StatePublished - Feb 1 2009

Fingerprint

T-Cell Antigen Receptor Specificity
T-Cell Antigen Receptor
Major Histocompatibility Complex
Peptides
T-Lymphocytes
Cluster Analysis
Epitopes
Ligands

Keywords

  • Agonists
  • Antagonists
  • Binding affinity
  • Coreceptors
  • Dissociation rate
  • Major histocompatibility complex
  • Peptide specificity
  • Peptide-major histocompatibility complex
  • Serial triggering
  • T-cell receptor
  • T-cell receptor clustering

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

T-cell receptor binding affinities and kinetics : impact on T-cell activity and specificity. / Stone, Jennifer D.; Chervin, Adam S.; Kranz, David M.

In: Immunology, Vol. 126, No. 2, 01.02.2009, p. 165-176.

Research output: Contribution to journalReview article

Stone, Jennifer D. ; Chervin, Adam S. ; Kranz, David M. / T-cell receptor binding affinities and kinetics : impact on T-cell activity and specificity. In: Immunology. 2009 ; Vol. 126, No. 2. pp. 165-176.
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