Systems biology understanding of the effects of lithium on cancer

Weihao Ge, Eric Jakobsson

Research output: Contribution to journalArticlepeer-review

Abstract

Lithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action. Multiple lines of evidence point to lithium as a significant factor in development of cancer, showing that understanding lithium action is of high importance. In this paper we undertake first steps toward a systems approach by analyzing mutual enrichment between the interactomes of lithium-sensitive enzymes and the pathways associated with cancer. This work integrates information from two important databases, STRING, and KEGG pathways. We find that for the majority of cancer pathways the mutual enrichment is statistically highly significant, reinforcing previous lines of evidence that lithium is an important influence on cancer.

Original languageEnglish (US)
Article number296
JournalFrontiers in Oncology
Volume9
Issue numberAPR
DOIs
StatePublished - 2019

Keywords

  • Biochemical networks
  • Biochemical pathways
  • Cancer
  • Gsk3b
  • Kinases
  • Lithium
  • Phosphotransferases
  • Systems biology

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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