System modeling and evaluation of a prototype inverted-compound eye gamma camera for the second generation MR compatible SPECT

Xiaochun Lai; Elena M. Zannoni; Jonathan George; Ling Jian Meng

doi:10.1016/j.nima.2019.04.001

System modeling and evaluation of a prototype inverted-compound eye gamma camera for the second generation MR compatible SPECT

Xiaochun Lai, Elena M. Zannoni, Jonathan George, Ling Jian Meng

Research output: Contribution to journal › Review article › peer-review

Abstract

We have reported the design of the MRC-SPECT-II system based on the inverted-compound-eye (ICE) gamma camera to offer a >1% detection efficiency while maintaining a sub-500μm imaging resolution (Lai and Meng, 2018). One of the key challenges of using the ICE camera for SPECT imaging is whether one could develop an accurate point response function (PRF), given its complex aperture design and low fractionation accuracy of 3D printing. In this work, we will discuss (I) a combined experimental and analytical approach for deriving the precise PRF, and (II) an experimental imaging study to demonstrate the feasibility of using the ICE-camera for acquiring high-quality SPECT images with a sub-500μm resolution. These studies would help to overcome one of the major hurdles for implement ICE-cameras for practical SPECT imaging.

Original language	English (US)
Article number	162046
Journal	Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume	954
DOIs	https://doi.org/10.1016/j.nima.2019.04.001
State	Published - Feb 21 2020
Externally published	Yes

Keywords

CdTe
Compound eye
SPECT modeling
SPECT/MRI

ASJC Scopus subject areas

Nuclear and High Energy Physics
Instrumentation

Online availability

10.1016/j.nima.2019.04.001

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Lai, X., Zannoni, E. M., George, J., & Meng, L. J. (2020). System modeling and evaluation of a prototype inverted-compound eye gamma camera for the second generation MR compatible SPECT. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 954, [162046]. https://doi.org/10.1016/j.nima.2019.04.001

System modeling and evaluation of a prototype inverted-compound eye gamma camera for the second generation MR compatible SPECT. / Lai, Xiaochun; Zannoni, Elena M.; George, Jonathan et al.

In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 954, 162046, 21.02.2020.

Research output: Contribution to journal › Review article › peer-review

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abstract = "We have reported the design of the MRC-SPECT-II system based on the inverted-compound-eye (ICE) gamma camera to offer a >1% detection efficiency while maintaining a sub-500μm imaging resolution (Lai and Meng, 2018). One of the key challenges of using the ICE camera for SPECT imaging is whether one could develop an accurate point response function (PRF), given its complex aperture design and low fractionation accuracy of 3D printing. In this work, we will discuss (I) a combined experimental and analytical approach for deriving the precise PRF, and (II) an experimental imaging study to demonstrate the feasibility of using the ICE-camera for acquiring high-quality SPECT images with a sub-500μm resolution. These studies would help to overcome one of the major hurdles for implement ICE-cameras for practical SPECT imaging.",

keywords = "CdTe, Compound eye, SPECT modeling, SPECT/MRI",

author = "Xiaochun Lai and Zannoni, {Elena M.} and Jonathan George and Meng, {Ling Jian}",

note = "Funding Information: This work was supported in part by NIH, USA grants R01-EB022388 and R21-EB018001 . Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

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System modeling and evaluation of a prototype inverted-compound eye gamma camera for the second generation MR compatible SPECT

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